The Effects of Taurine Supplementation on Obesity and Browning of White Adipose Tissue in High-Fat Diet-Fed Mice

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dc.authorid109356en_US
dc.authorid335226en_US
dc.contributor.authorÖkten, Hatice
dc.contributor.authorBağcı, Gökhan
dc.date.accessioned2023-03-14T07:12:29Z
dc.date.available2023-03-14T07:12:29Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: In recent years, a new type of adipose tissue (beige adipose tissue) has been mentioned, unlike white adipose tissue (WAT) and brown adipose tissue (BAT). Beige cells are capable of thermogenesis like BAT. In response to various agents, beige cells can develop within WAT through a process called “browning.” Therefore, the prevention of obesity and related diseases by providing WAT browning with new potential agents has been extensively studied in recent years. Taurine has many physiological functions in the body and has beneficial effects on obesity and related metabolic disorders. For this reason, we aimed to investigate whether taurine supplemen tation has effects on browning of WAT and attenuating obesity. Methods: Thirty-two male C57BL/6 mice were used for the study. Mice were divided into 4 groups as control, control+tau rine, high fat diet (HFD) and HFD+taurine, and fed for 20weeks. Taurine was given in drinking water (5%). Epididymal WAT samples were obtained from mice and RNA was extracted from these tissues. Expression levels of FLCN, mTOR, TFE3, PGC-1?, PGC1-1?, AMPK, S6K and UCP1 genes were measured by realtime PCR. Results: Taurine supplementation reduced HFD induced obesity. No UCP1 expression was detected in any of the groups studied. Any of the gene expressions were not significantly different between HFD and HFD+taurine groups. Reduced PGC-1? and PGC-1? expressions were observed in both HFD and HFD+ taurine groups. Conclusions: Taurine reduced the obesity in HFD fed mice, but had no effect on browning of epididymal WAT in this study.en_US
dc.identifier.doi10.1080/15257770.2022.2114597
dc.identifier.issn2619-9793
dc.identifier.pmid36000201en_US
dc.identifier.urihttps://doi.org/10.1080/15257770.2022.2114597
dc.identifier.wosWOS:000844093500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectTaurineen_US
dc.subjectObesityen_US
dc.subjectBeige adipose tissueen_US
dc.subjectBrowning of white adipose tissueen_US
dc.subjectHigh-fat dieten_US
dc.titleThe Effects of Taurine Supplementation on Obesity and Browning of White Adipose Tissue in High-Fat Diet-Fed Miceen_US
dc.typeArticleen_US

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