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Öğe The Relationship of Covıd-19 Related Anxiety with Positive and Negative Emotions of Individuals(Cyprus Mental Health Institute, 2022) Ünübol, Hüseyin; Özdoğan, Büşra; Hızlı Sayar, GökbenCovid-19 has emerged as a pandemic that has affected all humanity since the end of 2019 and has affected the mental health of individuals, causing anxiety, fear, uncertainty, and hopelessness. This study aimed to examine the relationship between anxiety caused by Covid-19 and positive and negative emotions. 3121 people with an average age of 31.3 (SD=10.20) were included in this cross-sectional study conducted online. Data were collected via Sociodemographic Information Form, Epidemic Anxiety Scale (EAS), and Positive and Negative Emotion Scale (PNES). In this study, a significant negative correlation was found between epidemic anxiety and positive emotions (r=-0.057; p<.001); A positive and significant relationship was found between epidemic anxiety and negative emotions (r=0.571; p<.001). A significant positive correlation was found between economic anxiety and negative emotions (r=-0.335; p<.001). A significant negative correlation was found between quarantine anxiety and positive emotions (r=-0.044; p<.05). A significant positive correlation was found between quarantine anxiety and negative emotions (r=0.534; p<.001). A significant positive correlation was found between social life anxiety and negative emotions (r=0.489; p<.001). The results of this research point out the relationship between positive and negative emotions and epidemic anxiety, economic anxiety, quarantine anxiety, and social life anxiety. This relationship can be in the form of anxieties affecting emotions, or it can be in the form of emotions affecting the level of anxiety. For this reason, while taking measures to calm anxiety in epidemic disease processes such as Covid-19, positive and negative emotions should be examined, and reparative measures should be taken.Öğe The Effects of Taurine Supplementation on Obesity and Browning of White Adipose Tissue in High-Fat Diet-Fed Mice(TAYLOR & FRANCIS INC, 2022) Ökten, Hatice; Bağcı, GökhanBackground: In recent years, a new type of adipose tissue (beige adipose tissue) has been mentioned, unlike white adipose tissue (WAT) and brown adipose tissue (BAT). Beige cells are capable of thermogenesis like BAT. In response to various agents, beige cells can develop within WAT through a process called “browning.” Therefore, the prevention of obesity and related diseases by providing WAT browning with new potential agents has been extensively studied in recent years. Taurine has many physiological functions in the body and has beneficial effects on obesity and related metabolic disorders. For this reason, we aimed to investigate whether taurine supplemen tation has effects on browning of WAT and attenuating obesity. Methods: Thirty-two male C57BL/6 mice were used for the study. Mice were divided into 4 groups as control, control+tau rine, high fat diet (HFD) and HFD+taurine, and fed for 20weeks. Taurine was given in drinking water (5%). Epididymal WAT samples were obtained from mice and RNA was extracted from these tissues. Expression levels of FLCN, mTOR, TFE3, PGC-1?, PGC1-1?, AMPK, S6K and UCP1 genes were measured by realtime PCR. Results: Taurine supplementation reduced HFD induced obesity. No UCP1 expression was detected in any of the groups studied. Any of the gene expressions were not significantly different between HFD and HFD+taurine groups. Reduced PGC-1? and PGC-1? expressions were observed in both HFD and HFD+ taurine groups. Conclusions: Taurine reduced the obesity in HFD fed mice, but had no effect on browning of epididymal WAT in this study.Öğe Predictors of High-Grade Residual Disease After Repeat Conization in Patients with Positive Surgical Margins(Via Medica, 2022) Salihoğlu, Mehmet Yavuz; vd.Objectives: No consensus exists on the subsequent management strategy of patients who exhibit positive surgical margin (PSM) after re-excision of high-grade cervical intraepithelial neoplasia (CIN). The aim of the study is to examine the predictors related to the persistence of high-grade CIN lesions after re-excision, where PSM was left behind. Material and methods: The present retrospective study included patients with PSM who underwent repeated conization due to residual high-grade CIN lesions between January 2005 and December 2019. The SPSS software v20.0 was used for data interpretation and statistical analysis. P values less than 0.05 were accepted as statistically significant. Results: Repeat conization was performed in 91 patients, 43 (47.3%) presented with PSM with high-grade CIN, 6 (6.5%) presented with micro-invasive carcinoma, and 42 (46.2%) presented with clear surgical margin or CIN 1 at the surgical margin. At the time of conization, patients who presented with lesions > 5 mm in repeat cone specimens, exhibited a significantly higher rate of residual disease (p < 0.001). Besides, the involvement of the endocervical margin with high-grade CIN was the predictor of residual disease in repeat cone specimens (p = 0.006). Conclusions: In the cone specimen, the presence of lesion size greater than 5 mm and involvement of the endocervical margin were the predictors of high-grade residual disease after re-excision. Whether it is the first or second procedure, great care must be given to excise the lesion entirely at the time of the conization, preferably in one pieceÖğe Possible Role of Endocannabinoids in Olfactory and Taste Dysfunctions in COVID-19 Patients and Volumetric Changes in the Brain(SPRINGER, 2022) Kaptan, ZülalIntroduction COVID-19 infection develops neurologic symptoms such as smell and taste loss. We aimed to determine the volumetric changes in the brain and correlation of possible related biochemical parameters and endocannabinoid levels after COVID-19 recovery. Methods Brain magnetic resonance images of recovered COVID-19 patients and healthy volunteers, whose olfactory and gustatory scores were obtained through a questionnaire, were taken, and the volumes of the brain regions associated with taste and smell were measured by automatic and semiautomatic methods. Endocannabinoids (EC), which are critical in the olfactory system, and vitamin B12, zinc, iron, ferritin, thyroid-stimulating hormone (TSH), and thyroxine (T4) levels, which are reported to have possible roles in olfactory disorders, were measured in peripheral blood. Results Taste and smell disorder scores and EC levels were found to be higher in recovered COVID-19 patients compared to controls. EC levels were negatively correlated with bilateral entorhinal cortex (ENT) volumes in the COVID-19 group. Subgenual anterior cingulate cortex volumes showed correlations with gustatory complaints and ferritin in recovered COVID 19 patients. Conclusions The critical fnding of our study is the high EC levels and negative correlation between EC levels and left ENT volumes in recovered COVID-19 patients. Implications It is possible that ECs are potential neuromodulators in many conditions leading to olfactory disorders, includ ing COVID-19.Öğe Prolonged post-ECT delirium associated With substance-induced psychosis: A case report(John Wiley and Sons Inc, 2022) Köroğlu, Emre; Ayrıbaş, BaşarElectroconvulsive therapy (ECT) is an effective treatment for various psychiatric conditions. Although rare, prolonged post?ECT delirium is a serious adverse effect of ECT. Various factors, such as underlying brain pathologies, medications, seizure duration, and type of electrode placements play a role in the development of post? ECT delirium. We report a 56?year?old male suffering from 14?day?long post?ECT delirium associated with substance misuse, pesticide exposure, as well as ischemic brain changes. On the basis of the insights from this case, it may be suggested that all patients should be screened for risk factors associated with ECT?related delirium before ECT and that various parameters, such as electrode placement and medica tions, should be adjusted accordinglÖğe Local Use of Rifampicin for Surgical Site Infection after Lumbar Microdiscectomy(COLL PHYSICIANS & SURGEONS PAKISTAN, 2022) Çetin, Eyüp; Yücel, MuratObjective: To investigate the effect of local use of rifampicin (RIF) on the development of postoperative surgical site infection (SSI) after lumbar microdiscectomy. Study Design: Observational study. Place and Duration of Study: Van YuzuncuYil University Medical School Neurosurgery Clinic, between 2020 and 2022. Methodology: This retrospective study reviewed the clinical and laboratory records of 178 patients who underwent lumbar microsurgery. After lumbar microsurgery, one ampoule of rifampicin (RIF) (250 mg) was locally injected into the surgical site in 62 patients (RIF group), while the remaining 116 patients (non-RIF group) received no injection into the surgical site after lumbar microsurgery. Normal distribution of data was analysed using Kolmogorov-Smirnov test. Continuous variables were compared using Mann-Whitney U test and categorical variables were compared using chi-square test or Fisher’s exact test as needed. Results: In the postoperative period, local infection developed in one patient in the RIF group, while local infection developed in 11 and deep infection developed in three of the patients in the non-RIF group. Moreover, the risk of local infection development was significantly higher in the non-RIF group compared to the RIF group. The rate of superficial SSI was lower in the RIF group compared to the non-RIF group. No significant difference was observed between the two groups with regard to the rate of deep SSI. Conclusion: Postoperative infection is an extremely important clinical condition manifesting in the form of superficial or deep SSI. The utmost care and necessary precautions should be taken to avoid postoperative infections. Intraoperative antibiotic prophylaxis is the most effective method in preventing postoperative spinal infections.Öğe Impact of Copper and Oxidative Stress Index Levels on Insulin Resistance, Lipid Profile and Hormonal Status of Patients with Polycystic Ovary Syndrome(ISTANBUL TRAINING & RESEARCH HOSPITAL, 2022) Atamer, Yıldız; vd.Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine abnormalities of reproductive age and has a highly heterogeneous nature regarding its multisystemic symptoms. To elicit pathophysiological roots, metabolic mapping and between-correlations among key parameters are of vital importance. We generated a platform including cardinal hormones, lipids, homeostasis model assessment of insulin resistance (HOMA-IR) and oxidative markers [total-oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), copper (Cu)] related to pathophysiology. Methods: This prospective case-control study included 46 patients with PCOS and 44 non-PCOS healthy women. Samples were obtained from the Obstetrics and Gynecology Clinic of University of Health Sciences Turkey, İstanbul Training and Research Hospital.TAS, TOS, and Cu levels were measured by automated methods. Results: Anti-Mullerian hormone, total testosterone (TT), dehydroepiandrosterone sulfate, low-density lipoprotein, high-density lipoprotein (HDL), total cholesterol, TOS, OSI were increased in patients with PCOS with no significant differences in the mean values of other parameters. ROC analysis revealed that TOS and OSI had an acceptable predictive value for PCOS diagnosis. Plasma HOMA-IR, triglyceride, HDL, TT, and sex-hormone-binding globulin levels were correlated with OS markers. Conclusion: Redox status was found to be sensitive to hormonal alterations. Metabolites were then were compared with the oxidative markers to reveal any relationship that may explain the causal link between metabolic and redox changes Ultimately, evaluating broad-based metabolic profiling of patients, the current study contributes to the literature, which has controversial data and correlation findings poses new questions requiring further research to elicit underlying mechanisms and so to set new targets for both prevention and treatment.Öğe Evaluation of the Coronal Malposition of the Volar Locking Plate in the Treatment of Distal Radius Fractures(CUREUS INC, 2022) Öç, Yunus; vd.Background and objectives: Literature does not show any studies regarding plate placement problems in the coronal plane of patients with volar plating due to distal radius fracture diagnosis. We aimed to investigate the functional and laboratory results of the coronal malposition of the volar locking plate in patients with distal radius fracture treated with internal fixation. Methods: In this retrospective study, we included patients who had volar plate fixation, were aged between 18 and 80, had no pathological fracture, had a minimum of six months of follow-up, and had the same rehabilitation protocol. We consider the angle subtended on the coronal axis between the distal radius long axis and the distal radius locking plate as coronal malposition. We named the coronal malposition angle the "AYE Angle." Patients with an AYE angle of over 1 degree were evaluated under group 1. Patients with an AYE angle of 0-1 degrees were evaluated under group 2. Radiological parameters were taken from AP-Lateral X-ray views. Superficial University System of Georgia (USG) examinations were applied to detect tendon problems. The DASH and QUICK-DASH scoring systems were used for clinical evaluation. Grip strength was measured with a dynamometer in all patients. All results were compared between the two groups. Results: Thirteen patients were female and 27 patients were male. Nineteen patients who had coronal malposition were added to group 1, while 21 patients who had no coronal malposition were added to group 2. Fifteen patients had normal USG results in group 2, while 18 patients had edema around the flexor pollicis longus (FPL) tendon as a result of USG in group 1. Statistically, a significant difference was detected between the two groups in terms of the amount of tenosynovitis around FPL (p=0.01). A statistically significant relationship was found between USG grading and malposition grading. The study revealed that a higher rate of USG grade 2 was found in patients with malposition grade 2 (90.9%), while a higher rate of USG grade 1 (50%) was observed in patients with malposition grade 1 (p=0.01). A statistically significant difference was not found between Soong grading and USG in terms of the level of tenosynovitis around the FPL tendon. The amount of tenosynovitis detected around the FPL tendon was 62.5% for Soong and grade 0 level, 60.7% for grade 1 level, and 50% for grade 2 level. There was no statistically significant difference between the two groups in the DASH and QUICK-DASH scoring systems (p=0.96). There was no statistically significant difference between the two groups in the grip strength(p=0.52). Conclusion: Coronal plate position in the treatment of the distal radius fracture is important to avoid potential flexor tendon problems. The volar plate position should be adjusted properly both in the coronal and sagittal axes.Öğe Effectiveness of Anodal otDCS Following with Anodal tDCS Rather than tDCS Alone for Increasing of Relative Power of Intrinsic Matched EEG Bands in Rat Brains(MDPI, 2022) Kaptan, Zulal; vd.Background: This study sought to determine whether (1) evidence is available of inter actions between anodal tDCS and oscillated tDCS stimulation patterns to increase the power of endogenous brain oscillations and (2) the frequency matching the applied anodal otDCS’s frequency and the brain’s dominant intrinsic frequency influence power shifting during stimulation pattern sessions by both anodal DCS and anodal oscillated DCS. Method: Rats received different anodal tDCS and otDCS stimulation patterns using 8.5 Hz and 13 Hz state-related dominant intrinsic frequencies of anodal otDCS. The rats were divided into groups with specific stimulation patterns: group A: tDCS–otDCS (8.5 Hz)–otDCS (13 Hz); group B: otDCS (8.5 Hz)–tDCS–otDCS (13 Hz); group C: otDCS (13 Hz)–tDCS–otDCS (8.5 Hz). Acute relative power changes (i.e., following 10 min stimulation ses sions) in six frequency bands—delta (1.5–4 Hz), theta (4–7 Hz), alpha-1 (7–10 Hz), alpha-2 (10–12 Hz), beta-1 (12–15 Hz) and beta-2 (15–20 Hz)—were compared using three factors and repeated ANOVA measurement. Results: For each stimulation, tDCS increased theta power band and, above bands alpha and beta, a drop in delta power was observed. Anodal otDCS had a mild increasing power effect in both matched intrinsic and delta bands. In group pattern stimulations, increased power of endogenous frequencies matched exogenous otDCS frequencies—8.5 Hz or 13 Hz—with more potent effects in upper bands. The power was markedly more potent with the otDCS–tDCS stimulation pattern than the tDCS–otDCS pattern. Significance: The findings suggest that the otDCS–tDCS pattern stimulation increased the power in matched intrinsic oscillations and, significantly, in the above bands in an ascending order. We provide evidence for the successful corporation between otDCS (as frequency-matched guidance) and tDCS (as a power generator) rather than tDCS alone when stimulating a desired brain intrinsic band (herein, tES specificity)Öğe Detection of Deregulated miRNAs in Childhood Epileptic Encephalopathies(SPRINGERNATURE, 2022) Hayretdağ, Ceyda; Ünalp, Aycan; vd.The term “epileptic encephalopathy” is used to describe a possible relationship between epilepsy and developmental delay. The pathogenesis of developmental encephalopathies, independent of epilepsy, can be defned by genetic control mechanisms. The aim of this study was to investigate the use of miRNAs as serum biomarkers for the determination and discrimination of epileptic encephalopathies. Whole blood samples obtained from 54 individuals in 2 groups designated as epilepticencepha lopathy patients’ group (n=24) and healthy controls (n=30) were included in this study. The expression levels of10 miRNAs were determined using qRT-PCR. After the determination of expression levels, the correlation of upregulated miRNA levels and Ki67 index was calculated using Pearson correlation test. The comparison of epileptic encephalopathy patients’ group with healthy controls revealed the upregulation of one miRNAs (hsa-miR-324-5p) and downregulation of three miRNAs (hsa-miR-146a-5p, hsa-miR-138-5p, hsa-miR-187-3p). It has been determined that miRNAs with altered expression are an important factor in the formation of epileptic seizures and seizure-induced neuronal death. The fact that processes that play a key role in epiloptogenesis are under the control of miRNAs causes miRNAs to become meta-controllers of gene expres sion in the brain.We thought that further studies are needed to prove that especially hsa-miR-146a-5p, hsa-miR-138-5p, and hsa-miR-187-3p can be used as epileptic encephalopathy biomarkers. The detection of disease-specifc miRNAs could contribute to the development of precision treatmentsÖğe Classification of Rat Mammary Carcinoma with Large Scale in Vivo Microwave Measurements(NATURE PORTFOLIO, 2022) Ateş Alkan, FatmaMammary carcinoma, breast cancer, is the most commonly diagnosed cancer type among women. Therefore, potential new technologies for the diagnosis and treatment of the disease are being investigated. One promising technique is microwave applications designed to exploit the inherent dielectric property discrepancy between the malignant and normal tissues. In theory, the anomalies can be characterized by simply measuring the dielectric properties. However, the current measurement technique is error-prone and a single measurement is not accurate enough to detect anomalies with high confdence. This work proposes to classify the rat mammary carcinoma, based on collected large-scale in vivo S11 measurements and corresponding tissue dielectric properties with a circular difraction antenna. The tissues were classifed with high accuracy in a reproducible way by leveraging a learning-based linear classifer. Moreover, the most discriminative S11 measurement was identifed, and to our surprise, using the discriminative measurement along with a linear classifer an 86.92% accuracy was achieved. These fndings suggest that a narrow band microwave circuitry can support the antenna enabling a low-cost automated microwave diagnostic system.Öğe A Three-year Retrospective Analysis of Vaginitis Agents in Patients Admitted to a Private Hospital(Kırıkkale Üniversitesi, 2022) Çağlar, Tülay; Erdem, Mustafa Genco; vd.Objective: In this study, we aimed to present the pathogens detected as vaginal infection agents isolated from vaginal swab samples in adult patients admitted to the Department of Gynecology and Obstetrics of a private hospital in Istanbul for three years retrospectively. Material and Methods: Vaginal swabs of adult non-pregnant patients admitted to Gynecology and Obstetrics outpatient clinics of a private hospital in Istanbul between 2016-2018 were included in this study. The samples were transferred quickly to the laboratory after sampling, and the infectious agents were identified with conventional bacterial culture methods. Results: Identification results of 314 vaginal swab samples revealed that 28 (8.92%) had C. albicans, 13 (5.73%) had pathogens that cause aerobic vaginitis, and five (1.59%) had bacterial vaginosis agents. C. albicans was the highest among agents with a frequency of 8.92%, followed by E. coli (2.23%). Conclusion: Our retrospective analysis revealed that C. albicans is the most frequent pathogen causing vaginitis in our hospital. As the pathogens causing vaginitis vary from region to region, we believe that monitorization of the epidemiological data is important.Öğe Ferric Carboxymaltose Versus Ferrous Glycine Sulfate for Treatment of Iron Deficiency Anemia and Their Effect on Vitamin B12 and Folic Acid: A Retrospective Study(Mustafa Hasbahçeci, 2022) Erdem, Mustafa GencoAim Anemia is a major public health problem, affecting about one-third of the world's population, and is most commonly caused by iron deficiency. Iron deficiency anemia requires oral or intravenous iron replacement therapy. The purpose of this study was to assess the change in several hematological parameters, vitamin B12, and folic acid from baseline to the first month of follow-up following therapy with oral ferrous glycine sulfate or intravenous ferric carboxymaltose. Methods: All patients who received oral ferrous glycine sulfate or intravenous ferric carboxymaltose for the treatment of iron deficiency anemia between January 1, 2016, and December 31, 2018, were included in the trial. Along with age and gender information, values of hemoglobin, ferritin, transferrin saturation, mean corpuscular volume, vitamin B12, and folic acid were derived from patients’ records at the beginning of treatment and first month follow-up. Results: Laboratory values obtained after treatment showed statistically significant improvement in both groups (intra group, p<0.001). When the percentage of change between groups was compared: Percentage-based increases in hemoglobin, mean corpuscular volume, transferrin saturation and ferritin values were significantly higher in the ferric carboxymaltose group (p<0.001). The percentage decrease in vitamin B12 and folic acid values was higher in the ferric carboxymaltose group (p=0.005 and p=0.01, respectively) when compared with oral ferrous glycine sulfate group. Conclusions: According to the findings of our study, iron deficiency anemia can be treated very successfully using ferric carboxymaltose; however, it should be remembered that concurrent supplementation of elements such vitamin B12 and folic acid is necessary for the appropriate progression of erythropoiesis.Öğe The effect of asthma controlling on heart rate recovery in patients with asthma(Annals of Medical Research, 2022) Çuğlan, Bilal; Akbaba Bağcı, Berna; Altıntaş, Mehmet Sait; Altundaş, EmineAim: The heart rate recovery index (HRRI) impairment was found in patients with pulmonary disease such as obstructive sleep apnea syndrome. Asthma is one of the most prevalent respiratory diseases in worldwide. In this study, we aimed to investigate the presence of HRRI impairment with asthma control test in patients with asthma. Material and Methods: A total of 45 people with asthma and 47 healthy participants were consequently enrolled to study from December 2019 through March 2020. The Asthma Control Test™(ACT) survey was used to evaluate the status of asthma. All participants were to undergo cardiopulmonary exercise testing. Heart rate recovery was calculated according to heart rate decreasing in recovery period. Results: Two groups had similar results in terms of laboratory parameters and demographic features. There was a statistically difference in exercise capacity, peak exercise heart rate, (METs) and duration of exercise. Also, all HRRI parameters were reached statistically significant when compared with control group. However, there was no statistically significance in HRRI when ACT groups were compared with each other. Conclusions: The differences of HRRI in ACT groups did not reach to statistically significance. This result could be a consequence of having only two ACT groups and not having any patients belonging to the well-controlled group.Öğe Enhanced External Counterpulsation Effects on Venous Leg Symptoms(Anatol J Cardiol, 2022) Çuğlan, Bilal; Turhan, Hasan; Yetkin, ErtanBackground: Venous diseases encompass a large spectrum of abnormalities in the venous system with complaints, such as aching and swelling. Enhanced external counterpulsation, proven safe and effective in patients with coronary artery disease and chronic heart failure, is a technique that increases venous return and augments diastolic blood pressure. This study assessed the effects of enhanced external counterpulsation on symptoms of venous disease using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms questionnaire. Methods: This study was designed prospectively for evaluating venous symptoms before and after enhanced external counterpulsation treatment. The study population consisted of 30 consecutive patients who were admitted to the cardiology clinic. The Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms questionnaire was applied to assess venous symptoms one day before and after enhanced external counterpulsation treatment. Results: The mean age of the patients was 64.62 ± 9.67 years. After 35 hours of enhanced external counterpulsation, 28 patients (93%) had at least 1 New York Heart Association functional class reduction compared with baseline and 43% of patients had 2 New York Heart Association functional classes improvement. The New York Heart Association class significantly decreased after enhanced external counterpulsation treatment (P< .001). There was a significant improvement in their swelling and night cramps symptoms compared with baseline (P< .001 and P = .05, respectively). Also, The left ventricular ejection fraction significantly increased after the enhanced external counterpulsation treatment (P = .02). Conclusions: The findings obtained in the present study suggested that patients treated with enhanced external counterpulsation showed a significant reduction in swelling and night cramps symptoms. Although the total VEIN score did not change after the enhanced external counterpulsation procedure, improvement in swelling and night cramps underlines the beneficial effects of enhanced external counterpulsation through the venous vascular territory.Öğe Thiopurine-S-Methyltransferase Gene Polymorphism and Drug-related Toxicity in Children Treated for Acute Leukemia and Non-Hodgkin’s Lymphoma(Galenos Publishing House, 2022) Aktan, Çağdaş; Ataseven, Eda; Kosova, Buket; Kurugöl, Zafer; Kantar, MehmetAim: Thiopurine S-methyltransferase (TPMT) is an essential enzyme in the metabolism of thiopurine drugs, and its activity may change due to different polymorphisms in the TPMT gene. The TPMT gene has different genetic polymorphisms in different ethnic groups. This study aimed to determine the frequency of TPMT polymorphisms in children with acute leukemia/non-Hodgkin lymphoma (AL/NHL) and healthy children and to evaluate their association with severe toxicities in the study population. Materials and Methods: Sixty-seven pediatric AL/NHL patients and 84 healthy children were evaluated. Genotyping for the TPMT*2, TPMT*3A, TPMT*3B, TPMT*3C, TPMT*4, TPMT*5, TPMT*6, and TPMT*7 alleles were performed by the real-time polymerase chain reaction technique. The number of grade 3 or higher hematologic and hepatic toxicities were recorded from the patient charts. Results: In the AL/NHL patients, we found that the patients had generally wild-type TPMT*1 allele in 80.6%, whereas TPMT*2 (238G>C) was seen in 1.5%, TPMT*3A (c.460G>A and c.719A>G) in 0%, and TPMT*3B polymorphisms (460G>A) in 17.9%. We found wild-type TPMT*1 allele in 98.8% and TPMT*3B polymorphisms (460G>A) in 1.2% of the healthy volunteers. Grade ?3 myelosuppression developed in 22/54 patients with the wild type allele, and it developed in 5/12 patients with TPMT*3B allele. Six (8.9%) patients had grade ?3 aspartate aminotransferase elevations, 17 (25%) patients had grade ?3 alanine transaminase elevations (1-5 times), and 42 patients had (62.6%) grade ?3 total bilirubin elevations. Conclusion: TPMT*3B polymorphism was the most common allele detected in our study group. This allele frequency is very high in comparison to other studies from our country and it was over-represented in comparison to the healthy volunteers. We did not find any relationship between severe hematologic/hepatic toxicities and TPMT gene polymorphisms.Öğe 90-day Readmission Rates After Cholecystectomy: A Retrospective Cohort Study(Permanyer, 2022) Karabay, Önder; vd.Objective: Although readmission after surgical procedures has been recognized as a new problem, its association with cholecystectomy has not been solved. We aimed to investigate the rate of unplanned readmission after cholecystectomy and to evaluate the reasons and outcomes in these patients. Methods: All consecutive patients who underwent open and laparoscopic cholecystectomy were retrospectively evaluated. Hospital readmission within the post-operative first 90 days after the procedure was searched. The rate and reasons for hospital readmission were the primary outcomes. Results: There were 601 patients with a mean age of 53.2 ± 12.4 years. The rate of readmission was 6.16%. Obesity (p = 0.001), number of coexisting disease (p = 0.039), conversion to open surgery (p = 0.002), development of intraoperative complications (p < 0.001), use of drain (p = 0.001), and length of hospital stay > 1 day (p = 0.024) were significantly associated with higher readmission rates. Biliary surgical causes were detected in five patients (12.8%). Non-biliary surgical causes were seen in 34 patients (87.2%). Among these, post-operative pain, nausea, and vomiting were the most common diagnoses in 25 (67.6%) and 5 patients (12.8%). Conclusion: The readmission rate after cholecystectomy is low. Significant predictive factors may help physicians to be alerted during the discharge of the patients. Post-operative pain, nausea, and vomiting were the most common diagnoses.Öğe Kömür Madeni Çalışanlarında Kalp Hızı Toparlanma İndekslerinin Değerlendirilmesi(MN Kardiyoloji, 2021) Çuğlan, Bilal; Altuntaş, EmineAmaç: Kardiyovasküler mortalitenin bağımsız öngördürücülerinden biri olan kalp hızı toparlanma indeksine kronik kömür tozu maruziyetinin bir etkisi olup olmadığını araştırmak. Gereç ve Yöntem: Hastane veri sisteminden Nisan 2016?Aralık 2017 arasında göğüs ağrısı ve nefes darlığı ile hastanemize başvuran ve muayene edilen 60 olgunun verilerine ulaşıldı. Çalışma iki gruptan oluşuyordu. Tüm olgular erkekti. 30 olgu aktif kömür madeni çalışanı (grup 1) iken, kalan 30 olgu sağlıklı kontrolleri oluşturmaktaydı (grup 2). Her iki grubun kan testi, egzersiz stres testi ve solunum fonksiyon testi sonuçları ile ekokardiyografik verileri kaydedildi. Bulgular: Yaş ortalaması grup 2’de 34,84±11,73 yıl iken; grup 1’de 38,26±5,28 yıl olup, iki grup arası istatistiksel fark yoktu (p=0,206). Hastaların dosyalarından egzersiz stres testi sonuçlarına ulaşıldı. İstatistiksel analize göre 1. dinlenme dakikasındaki kalp hızı toparlanma indeksi (KHTİ1), KHTİ3, KHTİ5 açısından gruplar arasında anlamlı fark oluşurken (sırasıyla p değeri 0,017; 0,034; 0,02); KHTİ 2 açısından gruplar arasında fark yoktu. KHTİ1, KHTİ3, KHTİ5 grup 2’de grup 1’e göre daha yüksekti. Sonuç: Bu çalışmada total ve kardiyovasküler mortaliteyi ön görmede önemli bir prediktör olan kalp hızı toparlanma indeksinin kömür madeni işçilerinde daha düşük olduğu saptanmıştır.Öğe Investigation of the Relationship Between Q-Fever Seropositivity and Trace Element Levels in Dairy Cattle(Kocatepe Veterinary Journal, 2021) Alkan, Fatma Ateş; Mavili, Zehra Seda; Dokuzeylül, Banu; Yaramış, Çağla Parkan; İkiz, Serkan; Saka, Sinem Ülgen; Or, Mehmet ErmanQuery fever (Q fever) which is caused by Coxiella burnetii is a continuing problem as a zoonotic disease in the world. In ruminants, infections are mostly asymptomatic however, abortions and stillbirths may occur during late pregnancy. Trace elements are important for the reproductive performance of ruminants and all have roles in immune function. However, serum trace element levels of Coxiella seropositive infertile and healthy dairy cows have not been investigated yet. The present was aimed to evaluate the trace element status of cattle associated with Coxiella burnetii. For this purpose, 200 dairy cattle with and without clinical problems (infertility, metritis and abortion) were compared. Q fever infection was confirmed with ELISA. Levels of trace elements of samples were analysed utilizing inductively coupled plasma-optical emission spectrophotometer. Serum levels of trace elements of the samples were expressed as ?g/mL. In total, 20 of 200 sera were diagnosed to be positive by ELISA. Nine of 20 sera were positive from asymptomatic cattle. Seven of 11 sera were positive from cattle with infertility, while 4 of 11 sera were positive from cattle with abortion. No significant differences were found between trace element levels of ELISA seropositive cattle and asymptomatic seropositive cattle. In conclusion, although statistical analysis of serum trace elements is no significant, our findings clearly show that analysis of trace element levels in cattle may be useful predictors in early treatment and prognosis. Further studies are required to clarify the connection between Coxiella seropositivity, trace elements and clinical symptoms in cattle.Öğe Determination of Antifungal Activity Against Invasive Candidiasis Agents and Trace Element Content of Fig Tree Latex Samples Obtained From Trabzon Province(International Journal of Advances in Engineering and Pure Sciences, 2021) Ünlü, Özge; Alkan, Fatma Ateş; Özsobacı, Nural Pastacı; Özyüksel, Sedanur; Demirci, MehmetCandidiasis is a major health concern causing both morbidity and mortality. The increasing prevalence of antimicrobialresistant fungi associated with life-threatening systemic mycoses, led a constant need for new antifungal agents. Herbalmedicines have been tried for this purpose for centuries. The antifungal effect of fig tree latex has been reported and some traceelements such as zinc were associated with antifungal effects. The aim of this study was to determine the trace element contentand in-vitro antifungal activity of fig tree latex sample against Candida. albicans, C. glabrata, C. tropicalis and C. krusei. Figtree latex samples were obtained from four different fig tree at Trabzon province in July 2019. The broth microdilutiontechnique was performed to investigate antifungal activity against standard Candida strains and trace elements level weredetected with Inductively Coupled Plasma Optical Emission Spectrophotometer (ICP-OES) analyzer. The most powerfulantifungal activity was reached at a concentration of 0.5 for C. albicans and C. tropicalis, and at a concentration of 0.125 forC. krusei and C. glabrata in fig tree latex. According to trace element analysis, magnesium had the highest level, followed bycalcium and phosphorus. Selenium, aluminium, lead and nickel levels were too low to be measured. As a conclusion, fig treelatex has an antifungal potential against Candida species and this may be caused by the high level of magnesium that it contains,however more studies are needed to understand the therapeutic effects of fig tree latex.
