İstanbul Beykent Üniversitesi Kurumsal Akademik Arşivi
DSpace@Beykent, İstanbul Beykent Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
One-pot Synthesis of Functionalized Benzimidazole-quinazolinone Derivatives
(Bentham Scıence, 28.04.2026) Beker, Hüseyin Kerim; Kaban, Seniz
Introduction/Objective: Quinazolinone and aldehyde derivatives have emerged as important molecules in recent studies because of their wide spectrum of pharmacological and biological effects. They have recently attracted attention in synthesis and research. Combinatorial synthesis for this type of heterocycle has emerged in the literature over the last decade. In one-pot processes, atypical intermediates often play key roles in the overall transformation. An unusual coupling sequence occurs through nucleophilic addition to an in situ-formed Michael intermediate. This is followed by an electrocyclic cyclization step. Motivated by these findings, we focused on designing a convenient synthetic method for the preparation of benzimidazole-quinazolinone and heteroaryl aldehyde derivatives. This study aimed to create efficient MCR pathways using common starting materials to build benzimidazole and quinazolinone scaffolds.
Methods: In this study, we performed a one-pot, three-component reaction. We reacted 2- aminobenzimidazole, various substituted heteroaryl aldehydes, and dimedone in absolute ethanol. Analytical and spectroscopic data (NMR, GC-MS, IR, and UV) were used to characterize and verify the structures of the synthesized complexes.
Results: The lead was compound 4a (88% yield). This route enables efficient heterocycle assembly. GC-MS analysis confirmed that compounds 4e and 4f share the same base peak (m/z 266), suggesting a common fragmentation pathway due to structural similarities.
Discussion: An efficient one-pot method for the synthesis of benzimidazole[2,1-b]quinazolinone derivatives was developed, avoiding multi-step procedures, and spectroscopic analyses confirmed the successful formation of the target compounds, demonstrating the practicality of the method.
Conclusion: The compounds obtained represent promising starting points for structural modification, which could lead to the development of more active quinazoline-based derivatives.
Thermoluminescence properties and trap kinetics of SmCa4(BO3)3 phosphor
(ScienceDirect, 01.03.2026) Şağban, Hüseyin Muzaffer; Çin, Elif Aymila; Bulcar, Kenan; Altowyan, Abeer S.; Çoban, Mustafa Burak; Kaynar, Ümit Hüseyin; Hakami, Jabir; Topaksu, Mustafa; Can, Nurdoğan
Undoped SmCa4O(BO3)3 (SCOB) phosphor was synthesized by a microwave-assisted sol–gel combustion method and confirmed as single-phase monoclinic by X-ray diffraction. Thermoluminescence (TL) was measured after β-irradiation up to 500 Gy at a linear heating rate of 2 °C/s between room temperature and 450 °C. The glow curve at 50 Gy shows two main peaks at about 80 °C and 240 °C; after optimized preheating at 180 °C for 10 s, a single dominant peak near 247 °C remains and is used for all further measurements. The main peak shows good reusability over repeated readouts and a wide dose–response range from ∼1 to about 500 Gy without saturation. Kinetic analysis of this peak using variable heating rate, initial rise, and glow-curve deconvolution yields activation energies around 1.6–1.8 eV and frequency factors of ∼1014–1016 s−1, indicating a thermally stable trapping level suitable for dosimetric applications.
Metformin attenuates fructose-induced pulmonary fibrosis, possibly through the involvement of the TRPC6 channel
(SciELO, 26.01.2026) Akbaş, Esra; Serez, Bilkay; Erçetin, Deniz; Aydın, Muhammet Ali; Sapmaz, Melike; Kaya, Oktay
Pulmonary fibrosis is a chronic, progressive, fatal lung disease characterized by abnormal lung tissue repair and intense collagen accumulation in the lungs. Despite intensive efforts, no specific treatment has been found. The aim of this study was to investigate the effects of a high-fructose diet on lung tissue, whether the use of metformin corrects the damage caused by high fructose, and the possible relationship with transient receptor potential (TRP) channels. Lung damage was induced by adding 200 g/L fructose to the drinking water of Sprague-Dawley rats (n=32) for 10 weeks. In the groups in which the effect of metformin was examined, metformin (dissolved in saline) was administered intraperitoneally at a dose of 100 mg/kg in the last two weeks of the study. Inflammation and TRP channel levels were measured by ELISA. Histopathological evaluation was also assessed by Masson's Trichrome staining. A high-fructose diet caused collagen deposition, inflammation, and intra-alveolar hemorrhage in lung tissue. Interleukin-6 and TRPC6 channel protein levels in lung tissue were higher in the high-fructose group than in the control group. These effects were prevented by metformin treatment. Metformin administration and manipulation of TRPC6 channels may be a therapeutic target for the treatment of pulmonary fibrosis.
Mechanical and Acoustic Performance of Lightweight Cementitious Composites Incorporating Pumice and Expanded Perlite
(MDPI, 27.05.2026) Yıldırım, Furkan; Emiroğlu, Mehmet
This study presents a comprehensive experimental investigation of lightweight cementitious composites incorporating pumice and expanded perlite as sustainable substitutes for conventional aggregate systems. Four replacement ratios (25%, 50%, 75%, and 100%) were evaluated to determine their effects on density, compressive strength, flexural strength, modulus of elasticity, and acoustic insulation properties, including the noise reduction coefficient (NRC) and frequency-dependent sound transmission loss (STL). The results showed that increasing the lightweight aggregate content generally reduced the strength-related mechanical properties while improving acoustic performance, particularly in the mid- and high-frequency ranges. Among all mixtures, the expanded perlite-based PRC-1.0 specimen exhibited the best overall acoustic performance, achieving the highest NRC value and the widest STL range. These findings demonstrate a clear trade-off between mechanical strength and acoustic efficiency, indicating that expanded perlite-based lightweight cementitious composites are promising materials for building applications requiring enhanced sound insulation performance.
ANN evaluation of thermodynamic efficiency, economic and environmental analysis of the geothermal-based electricity and hydrogen production system: A case study
(Energy, 30.09.2026) Barutçu, Ebru İnan; Karabuğa, Arif; Morozova, Sofya; Utlu, Zafer
This study presents a holistic artificial neural network (ANN)–assisted assessment of the thermodynamic, economic, and environmental performance of a geothermal-based integrated electricity and hydrogen production system. Based on real field data, two distinct operating scenarios are defined: in the S-1 configuration, the entire electricity generated by the Organic Rankine Cycle (ORC) is directed to hydrogen production via a proton exchange membrane (PEM) electrolyzer, whereas in the S-2 configuration the generated electricity is directly supplied to the grid. System performance is evaluated through thermodynamic modelling; the economic analysis is conducted using the levelized cost of energy (LCOE) methodology, and the environmental assessment quantifies avoided CO2 emissions together with natural gas savings. A multi-output ANN model developed using a dataset of 4776 observations is structured to simultaneously predict energy efficiency, exergy efficiency, hydrogen production rate, net power output, and cost indicators. The results indicate that the average exergy efficiencies of the S-1 and S-2 configurations are 6.57% and 7.73%, respectively. While the S-2 configuration appears economically advantageous due to lower LCOE values and shorter payback periods, the S-1 configuration delivers greater CO2 mitigation per unit hydrogen production from an environmental perspective. The ANN model demonstrates moderate predictive performance, with R2 values ranging from 0.47 to 0.67, MAE values as low as 0.000002, and MAPE values between 0.21% and 4.16%, indicating that the complex behaviour of geothermal–hydrogen systems can be reliably captured using data-driven approaches. The low error levels and high coefficients of determination obtained from the ANN model demonstrate that the complex behaviour of geothermal–hydrogen systems can be reliably captured using data-driven approaches. Rather than focusing solely on performance optimisation, this study proposes a multidimensional framework based on real operational data, providing a methodological guideline for the sustainable design and operation of geothermal-based multi-energy production systems.
