İstanbul Beykent Üniversitesi Kurumsal Akademik Arşivi
DSpace@Beykent, İstanbul Beykent Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Metformin attenuates fructose-induced pulmonary fibrosis, possibly through the involvement of the TRPC6 channel
(SciELO, 26.01.2026) Akbaş, Esra; Serez, Bilkay; Erçetin, Deniz; Aydın, Muhammet Ali; Sapmaz, Melike; Kaya, Oktay
Pulmonary fibrosis is a chronic, progressive, fatal lung disease characterized by abnormal lung tissue repair and intense collagen accumulation in the lungs. Despite intensive efforts, no specific treatment has been found. The aim of this study was to investigate the effects of a high-fructose diet on lung tissue, whether the use of metformin corrects the damage caused by high fructose, and the possible relationship with transient receptor potential (TRP) channels. Lung damage was induced by adding 200 g/L fructose to the drinking water of Sprague-Dawley rats (n=32) for 10 weeks. In the groups in which the effect of metformin was examined, metformin (dissolved in saline) was administered intraperitoneally at a dose of 100 mg/kg in the last two weeks of the study. Inflammation and TRP channel levels were measured by ELISA. Histopathological evaluation was also assessed by Masson's Trichrome staining. A high-fructose diet caused collagen deposition, inflammation, and intra-alveolar hemorrhage in lung tissue. Interleukin-6 and TRPC6 channel protein levels in lung tissue were higher in the high-fructose group than in the control group. These effects were prevented by metformin treatment. Metformin administration and manipulation of TRPC6 channels may be a therapeutic target for the treatment of pulmonary fibrosis.
Mechanical and Acoustic Performance of Lightweight Cementitious Composites Incorporating Pumice and Expanded Perlite
(MDPI, 27.05.2026) Yıldırım, Furkan; Emiroğlu, Mehmet
This study presents a comprehensive experimental investigation of lightweight cementitious composites incorporating pumice and expanded perlite as sustainable substitutes for conventional aggregate systems. Four replacement ratios (25%, 50%, 75%, and 100%) were evaluated to determine their effects on density, compressive strength, flexural strength, modulus of elasticity, and acoustic insulation properties, including the noise reduction coefficient (NRC) and frequency-dependent sound transmission loss (STL). The results showed that increasing the lightweight aggregate content generally reduced the strength-related mechanical properties while improving acoustic performance, particularly in the mid- and high-frequency ranges. Among all mixtures, the expanded perlite-based PRC-1.0 specimen exhibited the best overall acoustic performance, achieving the highest NRC value and the widest STL range. These findings demonstrate a clear trade-off between mechanical strength and acoustic efficiency, indicating that expanded perlite-based lightweight cementitious composites are promising materials for building applications requiring enhanced sound insulation performance.
ANN evaluation of thermodynamic efficiency, economic and environmental analysis of the geothermal-based electricity and hydrogen production system: A case study
(Energy, 30.09.2026) Barutçu, Ebru İnan; Karabuğa, Arif; Morozova, Sofya; Utlu, Zafer
This study presents a holistic artificial neural network (ANN)–assisted assessment of the thermodynamic, economic, and environmental performance of a geothermal-based integrated electricity and hydrogen production system. Based on real field data, two distinct operating scenarios are defined: in the S-1 configuration, the entire electricity generated by the Organic Rankine Cycle (ORC) is directed to hydrogen production via a proton exchange membrane (PEM) electrolyzer, whereas in the S-2 configuration the generated electricity is directly supplied to the grid. System performance is evaluated through thermodynamic modelling; the economic analysis is conducted using the levelized cost of energy (LCOE) methodology, and the environmental assessment quantifies avoided CO2 emissions together with natural gas savings. A multi-output ANN model developed using a dataset of 4776 observations is structured to simultaneously predict energy efficiency, exergy efficiency, hydrogen production rate, net power output, and cost indicators. The results indicate that the average exergy efficiencies of the S-1 and S-2 configurations are 6.57% and 7.73%, respectively. While the S-2 configuration appears economically advantageous due to lower LCOE values and shorter payback periods, the S-1 configuration delivers greater CO2 mitigation per unit hydrogen production from an environmental perspective. The ANN model demonstrates moderate predictive performance, with R2 values ranging from 0.47 to 0.67, MAE values as low as 0.000002, and MAPE values between 0.21% and 4.16%, indicating that the complex behaviour of geothermal–hydrogen systems can be reliably captured using data-driven approaches. The low error levels and high coefficients of determination obtained from the ANN model demonstrate that the complex behaviour of geothermal–hydrogen systems can be reliably captured using data-driven approaches. Rather than focusing solely on performance optimisation, this study proposes a multidimensional framework based on real operational data, providing a methodological guideline for the sustainable design and operation of geothermal-based multi-energy production systems.
Efficacy of Corkscrew-Tipped Telescopic Nail in the Management of Osteogenesis Imperfecta in Pediatric Patients
(European Journal of Pediatric Surgery, 29.05.2026) Alemdar, Celil; Sayar, Şafak; Atiç, Ramazan; Aydın, Abdulkadir; Yalvaç, Eyyüp Serdar; Demir, Sebahattin
Background
Telescopic intramedullary nailing is a cornerstone in the surgical management of pediatric osteogenesis imperfecta (OI), providing fracture prevention and deformity correction while accommodating bone growth. Nevertheless, implant-related complications remain a challenge affecting long-term outcomes.
Methods
This retrospective single-center study evaluated 13 pediatric patients with OI who underwent femoral fixation using corkscrew-tipped telescopic nails (CTTN) between 2014 and 2021. Demographic characteristics, Sillence classification, surgical indications, radiological outcomes, rod migration, complication, and revision rates were analyzed. Implant survival was assessed using Kaplan–Meier analysis.
Results
The study consisted of 7 female (53.8%) and 6 male (46.2%) patients, with a mean age of 9.2 ± 3.8 years. Most patients were classified as Sillence type IB (84.6%), with one patient each classified as Type IA and Type III. Rod migration occurred in three patients (23.0%) without distal joint penetration. Limited telescoping was observed in two femurs (15.2%). The revision rate was 23.0%, and the overall complication rate was 38.4%. Mean rod survival was 4.8 years (95% confidence interval [CI], 3.9–5.7).
Conclusion
CTTNs appear to be a feasible option for femoral fixation in pediatric patients with OI, avoiding joint arthrotomy and demonstrating acceptable complication and revision rates. However, lateral rod migration remains a notable limitation, indicating that adjunct stabilization techniques may be required.
NiCo2(SxSe1-x)4 sulfoselenide microspheres with optimized S/Se ratio for asymmetric supercapacitors
(Chemical Engineering Journal, 15.05.2026) Üstün, Burcu, Çolak, Süleyman Gökhan, Aydın, Hamide, Çolak, Melis Özge Alaş, Kurtaran, Ümran
Composition-engineered multi-anion transition-metal chalcogenides are promising electrode materials for high-performance supercapacitors because their anion chemistry can tune charge-transfer characteristics and redox utilization. In this study, a series of NiCo2(SxSe1-x)4 sulfoselenide microspheres with different S/Se ratios (NCSSe-0.4, NCSSe-0.5, and NCSSe-0.6) was synthesized by a hydrothermal route followed by post-annealing to establish how anion composition governs structure, kinetics, and device-level performance. The samples were characterized by XRD, SEM, N2 adsorption-desorption, and XPS, and their electrochemical behavior was evaluated in 6 M KOH by CV, GCD, EIS, and Dunn's kinetic analysis. Among the series, NCSSe-0.5 exhibited the best overall performance, delivering 835.7 F g−1 at 10 mV s−1 and 471.3 F g−1 at 1 A g−1. Kinetic analysis revealed diffusion-dominated battery-type charge storage for NCSSe-0.5, with a b-value of 0.38 and a diffusion contribution of 90.25% at 10 mV s−1. An asymmetric supercapacitor assembled using NCSSe-0.5 as the positive electrode and activated carbon as the negative electrode operated over 0.0–1.5 V, achieving 8.6 Wh kg−1 at 750 W kg−1 and 3.1 Wh kg−1 at 7500 W kg−1. These results show that tuning the S/Se ratio is an effective strategy for optimizing Nisingle bondCo sulfoselenide electrodes and clarifying the composition–structure–kinetics relationship relevant to asymmetric supercapacitor applications.
