Exploration Of Synergistic Antibiotic Interactions İn Klebsiella Pneumoniae

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dc.authorid107955en_US
dc.authorid115885en_US
dc.contributor.authorÜnlü, Özge
dc.contributor.authorYılancıoğlu, Kaan
dc.date.accessioned2020-10-16T11:11:21Z
dc.date.available2020-10-16T11:11:21Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractKlebsiella pneumoniae is an opportunistic pathogen resulting broad range of infections. Antimicrobial resistance causes a serious problem, which require immediate action. Treatment options are running out and the success rate of treatment is decreasing because of the strong multi-drug resistance. Synergistic antimicrobial combination therapy is a rational option with potential benefits. However, some antibiotic combinations might show antagonistic interaction patterns that hinder treatment efforts. Thus, screening drug interactions is crucial. In this study, we screened response of susceptible and multi-drug resistant K. pneumoniae strains to several antibiotic combinations. We used Amikacin, Ciprofloxacin, Kanamycin, Piperacillin, Ampicillin and Chloramphenicol in pairwise combinations. According to the results Kanamycin - Ciprofloxacin, Ampicillin - Piperacillin and Chloramphenicol - Piperacillin pairwise combinations were found as synergistic. Chloramphenicol - Amikacin and Chloramphenicol - Kanamycin combinations were found as antagonistic and Amikacin - Piperacillin and Kanamycin - Piperacillin combination were found as additive for both strains. Drug interaction is a complex mechanism. Different strains may respond differently to same combination treatments. Thus, each strain should be tested for drug interactions before combination therapy is given. In addition, antagonistic drug interactions should be considered.en_US
dc.identifier.citationRomanıan Bıotechnologıcal Letters 25,(1), 1246-1252, 2020en_US
dc.identifier.doi10.25083/rbl/25.1/1246.1252
dc.identifier.issn1572-1000
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.25083/rbl/25.1/1246.1252
dc.identifier.wosWOS:000524936900016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniversity of Bucharest,en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectAntibioticen_US
dc.subjectAntagonismen_US
dc.subjectSynergismen_US
dc.subjectDrug Interactionen_US
dc.titleExploration Of Synergistic Antibiotic Interactions İn Klebsiella Pneumoniaeen_US
dc.typeArticleen_US

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