Exploration Of Synergistic Antibiotic Interactions İn Klebsiella Pneumoniae
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Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Bucharest,
Erişim Hakkı
Özet
Klebsiella pneumoniae is an opportunistic pathogen resulting broad range of infections. Antimicrobial resistance causes a serious problem, which require immediate action. Treatment options are running out and the success rate of treatment is decreasing because of the strong multi-drug resistance. Synergistic antimicrobial combination therapy is a rational option with potential benefits. However, some antibiotic combinations might show antagonistic interaction patterns that hinder treatment efforts. Thus, screening drug interactions is crucial. In this study, we screened response of susceptible and multi-drug resistant K. pneumoniae strains to several antibiotic combinations. We used Amikacin, Ciprofloxacin, Kanamycin, Piperacillin, Ampicillin and Chloramphenicol in pairwise combinations. According to the results Kanamycin - Ciprofloxacin, Ampicillin - Piperacillin and Chloramphenicol - Piperacillin pairwise combinations were found as synergistic. Chloramphenicol - Amikacin and Chloramphenicol - Kanamycin combinations were found as antagonistic and Amikacin - Piperacillin and Kanamycin - Piperacillin combination were found as additive for both strains. Drug interaction is a complex mechanism. Different strains may respond differently to same combination treatments. Thus, each strain should be tested for drug interactions before combination therapy is given. In addition, antagonistic drug interactions should be considered.
Açıklama
Anahtar Kelimeler
Antibiotic, Antagonism, Synergism, Drug Interaction
Kaynak
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
Romanıan Bıotechnologıcal Letters 25,(1), 1246-1252, 2020
