Cytogenetic Analysis Of Early Pregnancy Loss After Assisted Reproduction Treatment Using İntracytoplasmic Sperm İnjection

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dc.authorid262746en_US
dc.authorid123001en_US
dc.contributor.authorHocaoğlu Emre, Fatma Sinem
dc.contributor.authorKamar, Aret
dc.contributor.authorTurktekin, Nurettin
dc.contributor.authorÖzyurt, Ramazan
dc.contributor.authorKarakuş, Cemil
dc.contributor.authorSarıbal, Devrim
dc.date.accessioned2021-04-19T12:17:11Z
dc.date.available2021-04-19T12:17:11Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjectives: To evaluate the incidence of numerical chromosomal abnormalities in the patients with early pregnancy loss (EPL) following in vitro fertilization, and evaluate the role of different confounders of the risk of chromosomal abnormality- related pregnancy loss. Material and methods: A retrospective chart review of all patients from our in vitro fertilization (IVF) center who conceived using assisted reproduction techniques between April 2017 and 2019, who experienced a subsequent early pregnancy loss, and whose abortus materials were successfully karyotyped were included. Results: Of the 243 patients experienced an early loss, the overall rate of chromosomal abnormality was 46.75%. The overall rate of aneuploidy in our patient group was 88.8% (64/72), whereas 6.94% (5/72) of the abnormal karyotypes were polyploid. The most common type of trisomy was Trisomy 16 (20.0%; 11/55) followed by Trisomy 15 (14.5%; 8/55). Univariate and multivariate analyses showed that maternal age (< 35 years) and the total number of retrieved oocytes per cycle (? 5) were risk factors for a chromosomal abnormality (< 0.001; < 0.05, respectively). The adjusted OR of karyotypic abnormalities was 0.45 for the antagonist cycle type (p < 0.05), and 0.58 for frozen embryo transfer (p < 0.05). Conclusions: Karyotypic abnormality is one of the main reasons for pregnancy loss following an IVF procedure. Although the pregnancy rates increased as a result of novel technologies, the ratio of EPL is still high. The implementation of preimplantation genetic screening techniques might lower the incidence of EPL due to chromosomal abnormalities, thus decreasing the burden on the physicians and the patients.en_US
dc.identifier.citationGinekologia Polska 2021, vol. 92en_US
dc.identifier.doi10.5603/GP.a2020.0147
dc.identifier.issn1879-0534
dc.identifier.pmid33844246en_US
dc.identifier.scopus2-s2.0-85112660865en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.5603/GP.a2020.0147
dc.identifier.wosWOS:000685202300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedica spen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectAbortusen_US
dc.subjectEarly pregnancy lossen_US
dc.subjectAssisted reproductionen_US
dc.subjectICSIen_US
dc.subjectCytogenetic analysisen_US
dc.titleCytogenetic Analysis Of Early Pregnancy Loss After Assisted Reproduction Treatment Using İntracytoplasmic Sperm İnjectionen_US
dc.typeArticleen_US

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