Synergistic Effect of Thymoquinone And Nystatin in The Treatment of Oral Candidiasis; an in Vitro Study

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dc.authorid243468en_US
dc.contributor.authorŞallı, Gülay Altan
dc.contributor.author.;, ve diğer
dc.date.accessioned2021-12-23T12:20:39Z
dc.date.available2021-12-23T12:20:39Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractThe effectiveness of antifungal agents may be insufficient against resistant strains in some cases of oral candidiasis. The aim of this study was to evaluate the antifungal effect of thymoquinone against Candidaalbicans, Candidatropicalis, Candidaglabrata and Candidakrusei strains and the synergistic antifungal activity of these strains in combination with nystatin. To evaluate in vitro antifungal activity and interactions between thymoquinone and nystatin, substances were tested against Candidaalbicans ATCC 10,231, C.tropicalis ATCC 750, C.krusei ATCC 6258 and C.glabrata ATCC 2001 standard strains both individually and combinationally via microdilution method. MIC and sigma FIC index value were analysed. The Kruskal Wallis test and Bonferroni test were used for statistical evaluations. Statistical significance was set at p < 0.05. A statistically significant difference was observed between the mean ranks of all Candida species and doses of thymoquinone, nystatin, and the combination thymoquinone-nystatin (p < 0.05). MIC values for thymoquinone were determined as 15 mu g/mL for C.albicans, C.tropicalis and C.krusei while it was 30 mu g/mL for C.glabrata. Moreover, MIC for nystatin was found as 1.875 mu g/mL for C.albicans, C.tropicalis and C.krusei, whereas it was 7.5 mu g/mL in C. glabrata. Interaction assays and sigma FIC index value revealed that, TQ and nystatin have a synergistic effect against to all strains. Thymoquinone was found to have antifungal activity on Candida species and synergistic effect when combined with nystatin.en_US
dc.identifier.citationOdontology (2021)en_US
dc.identifier.doi10.1007/s10266-021-00667-4
dc.identifier.issn0922-6567
dc.identifier.pmid34657217en_US
dc.identifier.scopus2-s2.0-85117572071en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s10266-021-00667-4
dc.identifier.wosWOS:000707922100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectThymoquinoneen_US
dc.subjectCandidaen_US
dc.subjectAntifungal drugsen_US
dc.subjectSynergistic efecten_US
dc.subjectOral candidiasisen_US
dc.titleSynergistic Effect of Thymoquinone And Nystatin in The Treatment of Oral Candidiasis; an in Vitro Studyen_US
dc.typeArticleen_US

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