Biological Variation Of Glycated Albumin, Glucose And Albumin İn Healthy Turkish Subjects

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dc.authorid262746en_US
dc.authorid274850en_US
dc.authorid301104en_US
dc.contributor.authorHocaoğlu Emre, Fatma Sinem
dc.contributor.authorMercan, Hilal
dc.contributor.authorOğuz, Osman
dc.date.accessioned2021-12-21T14:18:20Z
dc.date.available2021-12-21T14:18:20Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjectives: Biological variation (BV) in laboratory tests can be defined as the variation in analyte concentration over time within and between individuals. Glycated albumin (GA) is a ketoamine which is used in the short-term monitoring of diabetes. The aim of this research was to determine BV of GA, glucose, and albumin under a well-designed and standardized protocol. Methods: Blood samples were collected weekly from 21 healthy subjects (10 males, 11 females) for four consecutive weeks. Samples were analyzed using enzymatic methods in duplicate. After subjected to outlier and normality tests, variables as the within-subject biologic coefficient of variation (CVI) and between-subject biologic coefficient of variation (CVG), the index of individuality (II), and reference change value (RCV) were calculated. Results: Analytical coefficient of variation (CVA) was 3.5, 1.78, and 2.9%, for GA, glucose and albumin, respectively. The estimates for CVI and CVG: GA: 4.1%, 6.3%; glucose: 3.8%, 4.8%; albumin: 3.5%, 4%. RCVs and IIs were: 15%, 0.60; 12%, 0.79; 13%, 0.9 for GA, glucose and albumin, respectively. Conclusions: The BV data of GA derived from this study might be applied to understand routine test results better and establish the quality standards for the analyte. Keywordsen_US
dc.identifier.citationTurk J Biochem 2021; 46(2): 197–203en_US
dc.identifier.doi10.1515/tjb-2020-0115
dc.identifier.issn1303-6165
dc.identifier.scopus2-s2.0-85106217901en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.trdizinid492692en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/492692
dc.identifier.urihttps://doi.org/10.1515/tjb-2020-0115
dc.identifier.wosWOS:000646210300010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDe Gruyter [Commercial Publisher]en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectBetween-subject variationbiologicalen_US
dc.subjectBiological variationen_US
dc.subjectGlycated albuminen_US
dc.subjectReference change valuesen_US
dc.subjectWithin-subject variationen_US
dc.titleBiological Variation Of Glycated Albumin, Glucose And Albumin İn Healthy Turkish Subjectsen_US
dc.typeArticleen_US

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