Biological Variation Of Glycated Albumin, Glucose And Albumin İn Healthy Turkish Subjects

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De Gruyter [Commercial Publisher]

Erişim Hakkı


Objectives: Biological variation (BV) in laboratory tests can be defined as the variation in analyte concentration over time within and between individuals. Glycated albumin (GA) is a ketoamine which is used in the short-term monitoring of diabetes. The aim of this research was to determine BV of GA, glucose, and albumin under a well-designed and standardized protocol. Methods: Blood samples were collected weekly from 21 healthy subjects (10 males, 11 females) for four consecutive weeks. Samples were analyzed using enzymatic methods in duplicate. After subjected to outlier and normality tests, variables as the within-subject biologic coefficient of variation (CVI) and between-subject biologic coefficient of variation (CVG), the index of individuality (II), and reference change value (RCV) were calculated. Results: Analytical coefficient of variation (CVA) was 3.5, 1.78, and 2.9%, for GA, glucose and albumin, respectively. The estimates for CVI and CVG: GA: 4.1%, 6.3%; glucose: 3.8%, 4.8%; albumin: 3.5%, 4%. RCVs and IIs were: 15%, 0.60; 12%, 0.79; 13%, 0.9 for GA, glucose and albumin, respectively. Conclusions: The BV data of GA derived from this study might be applied to understand routine test results better and establish the quality standards for the analyte. Keywords


Anahtar Kelimeler

Between-subject variationbiological, Biological variation, Glycated albumin, Reference change values, Within-subject variation


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Turk J Biochem 2021; 46(2): 197–203