Determination of Antifungal Activity Against Invasive Candidiasis Agents and Trace Element Content of Fig Tree Latex Samples Obtained From Trabzon Province


Candidiasis is a major health concern causing both morbidity and mortality. The increasing prevalence of antimicrobialresistant fungi associated with life-threatening systemic mycoses, led a constant need for new antifungal agents. Herbalmedicines have been tried for this purpose for centuries. The antifungal effect of fig tree latex has been reported and some traceelements such as zinc were associated with antifungal effects. The aim of this study was to determine the trace element contentand in-vitro antifungal activity of fig tree latex sample against Candida. albicans, C. glabrata, C. tropicalis and C. krusei. Figtree latex samples were obtained from four different fig tree at Trabzon province in July 2019. The broth microdilutiontechnique was performed to investigate antifungal activity against standard Candida strains and trace elements level weredetected with Inductively Coupled Plasma Optical Emission Spectrophotometer (ICP-OES) analyzer. The most powerfulantifungal activity was reached at a concentration of 0.5 for C. albicans and C. tropicalis, and at a concentration of 0.125 forC. krusei and C. glabrata in fig tree latex. According to trace element analysis, magnesium had the highest level, followed bycalcium and phosphorus. Selenium, aluminium, lead and nickel levels were too low to be measured. As a conclusion, fig treelatex has an antifungal potential against Candida species and this may be caused by the high level of magnesium that it contains,however more studies are needed to understand the therapeutic effects of fig tree latex.


Anahtar Kelimeler

Fig tree latex, Ficus carica, Candida, Antifungal activity, Trace elements


WoS Q Değeri

Scopus Q Değeri




Int. J. Adv. Eng. Pure Sci. 2021, 33(3):499-504