In Vitro Effects Of Methylsulphonylmethane İn Mcf7 Cells

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dc.authorid260725en_US
dc.authorid298444en_US
dc.contributor.authorAktan, Çağdaş
dc.contributor.authorYıldırım, Işıl
dc.date.accessioned2020-10-16T11:08:21Z
dc.date.available2020-10-16T11:08:21Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractMethylsulphonylmethane (MSM) is the best source of organic sulfur with the best bio-utilization in the body. MSM provides Sulphur support to fragile tissues such as hair. It provides elasticity to connective tissue. It is required for collagen production. Despite its many advantages, there are only few published papers about the anticancer research regard to MSM, no known studies on Bioinformatics Analysis and the possible mechanisms such an effect remain unknown. Therefore, we aimed to investigate the anticancer effects of MSM associated with a bioinformatics analysis on the breast cancer cell MCF7 and to give the information about possible molecular mechanisms. A cytotoxicity assay was performed using the MTT method. The cell migration analysis was performed using wound healing analysis. An apoptotic effect was performed by DNA fragmentation analysis. A Bioinformatics analysis was performed using a protein data bank. Study results indicated that this component exhibited an anti-proliferative effect as based on dosage increases and it showed apoptotic effects at high concentrations on MCF7 cells and results were supported by previous studies. Consequently, a detailed study of the molecular mechanisms of this matter would allow for the identification of possible new targets for breast cancer treatments.en_US
dc.identifier.citationJournal Of Research In Pharmacy, 24(3), 326-333 2020en_US
dc.identifier.doi10.35333/jrp.2020.154
dc.identifier.issn1434-6044
dc.identifier.scopus2-s2.0-85088616497en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.trdizinid377860en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/377860
dc.identifier.urihttps://doi.org/10.35333/jrp.2020.154
dc.identifier.wosWOS:000536734800003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara University Pressen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectMethylsulphonlymethaneen_US
dc.subjectApoptosisen_US
dc.subjectCytotoxicityen_US
dc.subjectCysteineen_US
dc.subjectBioinformatics analysisen_US
dc.titleIn Vitro Effects Of Methylsulphonylmethane İn Mcf7 Cellsen_US
dc.typeArticleen_US

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