Correction To: Propofol But Not Dexmedetomidine Produce Locomotor Sensitization Via Nitric Oxide İn Rats

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dc.authorid247169en_US
dc.authorid201023en_US
dc.authorid12488en_US
dc.contributor.authorŞenöz, Ayşe Özçetin
dc.contributor.authorUskur, Tuğçe
dc.contributor.authorÇevreli, Burcu
dc.contributor.authorBarlas, Aydın
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2021-04-19T12:16:35Z
dc.date.available2021-04-19T12:16:35Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractRationale: The abused potential of some anesthetics has been debated. Measurement of locomotor sensitization is a better way to detect the neurobehavioral plasticity of addiction. Objectives: The present study aims to explore whether propofol and dexmedetomidine are capable of inducing locomotor sensitization. Methods: Male Wistar rats (250-300 g) were the subjects (n = 8 for each group). Propofol (20 and 40 mg/kg) and dexmedetomidine (2.5-20 ?g/kg) or saline were injected to rats intraperitoneally (IP), and their locomotor activities were recorded for 15 min. Consequently, L-NAME (30 and 60 mg/kg)-a nitric oxide (NO) inhibitory agent-was injected to rats 30 min before propofol (40 mg/kg) or saline injections, and the locomotor activity was recorded. The process was carried out for 13 days, with 7 sessions applied every other day. Results: Dexmedetomidine did not produce any significant locomotor sensitization. While propofol (20 mg/kg) produced a significant locomotor sensitization in the last treatment session (day 13), at the higher dose, it prompted a significant locomotor sensitization from the 3rd treatment session. L-NAME blocked propofol-induced locomotor hyperactivity and sensitization significantly without producing any noteworthy changes on the locomotor activity during the testing period of 13 days when administered alone. Conclusions: Our results suggest that propofol but not dexmedetomidine produced a significant locomotor sensitization via central nitrergic system. Dexmedetomidine may have a lesser psychostimulant type addictive potential than propofol. Sensitization development by propofol implies that this drug might be effective on the neuroadaptive processes associated with a stimulant type of dependence.en_US
dc.identifier.citationPsychopharmacology (2021) 238:579en_US
dc.identifier.doi10.1007/s00213-020-05724-4
dc.identifier.issn1079-7114
dc.identifier.pmid33216168en_US
dc.identifier.scopus2-s2.0-85096295878en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00213-020-05724-4
dc.identifier.wosWOS:000591130100002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisher(EBPS)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectDexmedetomidineen_US
dc.subjectL-NAMEen_US
dc.subjectLocomotor sensitizationen_US
dc.subjectPropofolen_US
dc.subjectRat(s)en_US
dc.titleCorrection To: Propofol But Not Dexmedetomidine Produce Locomotor Sensitization Via Nitric Oxide İn Ratsen_US
dc.typeArticleen_US

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