Assocıatıon Of The Seh Gene Promoter Polymorphısms And Haplotypes Wıth Preeclampsıa

Basit Öğe Kaydı
dc.authorid109356en_US
dc.authorid260725en_US
dc.authorid101987en_US
dc.contributor.authorÖkten, Hatice
dc.contributor.authorAktan, Çağdaş
dc.contributor.authorSarı, İsmail
dc.contributor.authorCihad, Esra
dc.date.accessioned2020-10-23T14:06:10Z
dc.date.available2020-10-23T14:06:10Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: The epoxyeicosatrienoic acids (EETs) have antihypertensive, anti-inflammatory, and organ protective properties and their circulation levels are related to hypertension, diabetes mellitus, cardiovascular diseases, and preeclampsia. Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids. Here, we sequenced the promoter region of EPHX2 to investigate the association between promoter sequence alterations that we thought to affect the expression levels of the enzyme and preeclampsia (PE). Methods: Nucleotide sequencing of the promoter region of the EPHX2, spanning from position -671 to +30, was performed on 100 pregnant women with PE and, 20 or more weeks pregnant normotensive, healthy women (n=100). Results: Pregnant women who carry rs4149235, rs4149232, rs73227309, and rs62504268 polymorphisms have 4.4, 2.4, 2.3, and 2.8 times significantly increased risk of PE, respectively. CCGG (OR: 3.11; 95% CI: 1.12-8.62) and CCCA (OR: 0.45; 95% CI: 0.36-0.55) haplotypes were associated with an increased and decreased risk of PE, respectively. Conclusions: Four SNPs (rs4149232, rs4149235, rs73227309, and rs62504268) in the promoter region of the EPHX2, and CCGG and CCCA haplotypes of these 4 SNPs were significantly associated with PE. These SNPs in the promoter region may affect sEH expression and enzyme activity and may play a role in PE pathogenesis by causing individual differences in EET levels. However, future studies are needed to confirm our findings and examine the effect of these SNPs on the sEH expression and/or enzyme activity.en_US
dc.identifier.citationJ Med Biochem 2020; 39 (4)en_US
dc.identifier.doi10.5937/jomb0-27745
dc.identifier.issn1079-7114
dc.identifier.pmid33312058en_US
dc.identifier.scopus2-s2.0-85099127497en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.5937/jomb0-27745
dc.identifier.wosWOS:000575084800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSCIndeksen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectEpoxyeicosatrienoic acidsen_US
dc.subjectPreeclampsiaen_US
dc.subjectSoluble epoxide hydrolaseen_US
dc.subjectPolymorphismen_US
dc.subjectGene promoteren_US
dc.titleAssocıatıon Of The Seh Gene Promoter Polymorphısms And Haplotypes Wıth Preeclampsıaen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
02 Assocıatıon Of The Seh Gene Promoter Polymorphısms And Haplotypes Wıth Preeclampsıa.pdf
Boyut:
226.11 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu