Epilepsy Frequency and Risk Factors Three Years After Neonatal Seizures

Basit Öğe Kaydı
dc.contributor.authorAltinbezer, Pelin
dc.contributor.authorColak, Ruya
dc.contributor.authorCalkavur, Sebnem
dc.contributor.authorYilmaz, Unsal
dc.date.accessioned2024-03-13T10:35:08Z
dc.date.available2024-03-13T10:35:08Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: Neonatal seizures, one of the main risk factors for the development of epilepsy, remain a clinical concern. In children with neonatal seizures, early recognition of risk factors is important for the early diagnosis and appropriate treatment of epilepsy and for improving prognosis. In this study, we aimed to determine the frequency of and the risk factors for the development of epilepsy in patients with neonatal seizures.Methods: The hospital files of 228 children who experienced seizures in the neonatal period were reviewed. The frequency of epilepsy and risk factors for the development of epilepsy were determined at age 36 months.Results: Epilepsy was diagnosed in 40.8% of the cases. Univariate analysis revealed family history of epilepsy, parental consanguinity, abnormal neurological examination findings, microcephaly, unresponsiveness to antiepileptic drugs or antiseizure medication, use of more than one antiepileptic drugs to antiseizure medication at discharge, status epilepticus, electroencephalography abnormalities, abnormal neuroimaging findings, invasive ventilation requirement, myoclonic seizures, central nervous system malformation, and congenital metabolic disease as risk factors for the development of epilepsy. Of these, a family history of epilepsy, abnormal neurological examination findings at discharge, and use of at least two antiepileptic drugs to antiseizure medication at discharge were found as independent risk factors in multivariate analysis.Conclusions: Neonatal seizures appear to be associated with epilepsy in more than one-third of the patients. Of the newborns with seizures, those with a family history of epilepsy, abnormal neurological examination findings at discharge, and those using at least two antiepileptic drugs to antiseizure medication at discharge should be monitored more carefully for the development of epilepsy.(c) 2023 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pediatrneurol.2023.09.015
dc.identifier.endpage126en_US
dc.identifier.issn0887-8994
dc.identifier.issn1873-5150
dc.identifier.pmid37866139en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1016/j.pediatrneurol.2023.09.015
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4256
dc.identifier.volume149en_US
dc.identifier.wosWOS:001103890700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeonatal seizuresen_US
dc.subjectEpilepsyen_US
dc.subjectOutcomeen_US
dc.subjectNewbornen_US
dc.subjectRisk factorsen_US
dc.titleEpilepsy Frequency and Risk Factors Three Years After Neonatal Seizuresen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu