The Probable Destructive Mechanisms Behind Covıd-19 On Male Reproduction System And Fertility

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dc.authorid282485en_US
dc.contributor.authorFındıklı, Necati
dc.contributor.authorMoshref, Mojgan
dc.contributor.authorGhasemi-Esmailabad, Saeed
dc.contributor.authorAli, Jaffar
dc.contributor.authorMangoli, Esmat
dc.contributor.authorKhalili, Mohammad Ali
dc.date.accessioned2021-09-06T13:08:46Z
dc.date.available2021-09-06T13:08:46Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractPurpose The present study aims to summarize the current understanding of probable mechanisms and claims of adverse effects of SARS-CoV-2 on male fertility potential. Methods Our search was including original articles, reviews, guidelines, letters to the editor, comments on guidelines, and editorials, regarding the male reproductive system. We used the words SARS-CoV-2, coronavirus, severe acute respiratory syndrome coronavirus 2, "2019 ncov," testis, sperm, male factor infertility, fertility treatment, semen, assisted reproductive technology (ART), sexual transmission, and ACE2. Results Data showed coronavirus affects men more than women because of more expression of 2019 nCoV receptors (ACE2 and TMPRSS2) in testicular cells. Also, "Bioinformatics Analysis" suggests that sperm production may be damaged, since "Pseudo Time Analysis" has shown disruption in spermatogenesis. "Gene Ontology" (GO) showed an increase in viral reproduction and a decrease in sperm production-related terms. Recently, SARS-COV-2 mRNA and protein were detected in the semen of patients that had recovered from SARS-CoV-2 infection. Therefore, the probable disruption of blood-testis barrier (BTB) in febrile diseases is suspected in the acute phase of the disease enabling viral entry into the testes. Not only is spermatogenesis disturbed, but also disturbs gonadotropin, androgens, and testosterone secretion during SARS-CoV-2 infection. No sexual transmission has been reported yet; however, detection of the virus in semen still makes the sexual transmission an open question. Conclusion There is a concern that male fertility may be disturbed after the SARS-CoV-2 infection. Therefore, follow-up of the reproductive functions and male fertility may be necessary in recovered cases, especially in aged men.en_US
dc.identifier.citationJournal of Assisted Reproduction and Genetics (2021) 38:1691–1708en_US
dc.identifier.doi10.1007/s10815-021-02097-1
dc.identifier.issn1029-8479
dc.identifier.pmid33977466en_US
dc.identifier.scopus2-s2.0-85105907322en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-021-02097-1
dc.identifier.wosWOS:000649215600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer [Commercial Publisher]en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectSpermen_US
dc.subjectTestisen_US
dc.subjectMale reproductionen_US
dc.titleThe Probable Destructive Mechanisms Behind Covıd-19 On Male Reproduction System And Fertilityen_US
dc.typeArticleen_US

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