Efeitos Antimicrobianos Do Fentanil E Da Bupivacaína: Estudo İn Vitro

Demirci, Mehmet; Kesici, Sevgi; Kesici, Uğur

Efeitos Antimicrobianos Do Fentanil E Da Bupivacaína: Estudo İn Vitro

dc.authorid	243533	en_US
dc.contributor.author	Demirci, Mehmet
dc.contributor.author	Kesici, Sevgi
dc.contributor.author	Kesici, Uğur
dc.date.accessioned	2020-10-23T14:06:07Z
dc.date.available	2020-10-23T14:06:07Z
dc.date.issued	2020
dc.department	İstanbul Beykent Üniversitesi	en_US
dc.description.abstract	Study objective: In this study, we aimed to compare the antimicrobial effects of bupivacaine and fentanyl citrate and to reveal the impact on antimicrobial effect potential in the case of combined use. Design: In vitro prospective study. Setting: University Clinical Microbiology Laboratory. Measurements: In our study, in vitro antimicrobial effect of 0.05 mg.mL(-1) fentanyl citrate, 5 mg.mL(-1) bupivacaine were tested against Staphylococcus aureus American Type Culture Collection (ATCC) 29213, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 13883, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231 as Group F (Fentanyl Citrate) and Group B (Bupivacaine), respectively. S. aureus ATCC 29213, P. aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 13883 and Escherichia coli ATCC 25922 were cultured onto Mueller Hinton agar (Oxoid, UK) plates and Candida albicans ATCC 10231 were cultured onto Sabouraud dextrose agar (Oxoid, UK) plates for 18-24 hours at 37 degrees c. Main results: In terms of inhibition zone diameters, S. Aureus ATCC 29213, P. aeruginosa ATCC 27853, and C. albicans ATCC 10231 values obtained after 12 and 24 hours of incubation were significantly higher in Group F than Group B (p < 0.001). In terms of inhibition zone diameters, E. coli ATCC 25922, and K. pneumomiae ATCC 13883 values obtained after 12 and 24 hours of incubation were significantly higher in Group B than Group F (p < 0.001, E. coli 122. hour p = 0.005). Conclusions: Addition of fentanyl to Local Anesthetics (LAs) is often preferred in regional anesthesia applications in today's practice owing especially to its effect on decreasing the local anesthetic dose and increasing analgesia quality and patient satisfaction. However, when the fact that fentanyl antagonized the antimicrobial effects of LAs in the studies is taken into account, it might be though that it contributes to an increase in infection complications. When the fact that fentanyl citrate, which was used in our study and included hydrochloric acid and sodium hydroxide as protective agents, broadened the antimicrobial effect spectrum of LAs, had no antagonistic effect and showed a synergistic antimicrobial effect against E. Coli is considered, we are of the opinion that the addition of fentanyl to LAs would contribute significantly in preventing the increasing regional anesthesia infection complications. (C) 2020 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.	en_US
dc.identifier.citation	Revısta Brasıleıra De Anestesıologıa, 70(4), 357-363	en_US
dc.identifier.doi	10.1016/j.bjan.2020.04.010
dc.identifier.issn	2158-2440
dc.identifier.pmid	32819727	en_US
dc.identifier.scopus	2-s2.0-85089512921	en_US
dc.identifier.scopusquality	Q2	en_US
dc.identifier.uri	https://doi.org/10.1016/j.bjan.2020.04.010
dc.identifier.wos	WOS:000573181100008	en_US
dc.identifier.wosquality	Q4	en_US
dc.indekslendigikaynak	Web of Science	en_US
dc.indekslendigikaynak	Scopus	en_US
dc.indekslendigikaynak	PubMed	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı	en_US
dc.subject	Antimicrobiano	en_US
dc.subject	Bupivacaína	en_US
dc.subject	Fentanil	en_US
dc.subject	Anestesia regional	en_US
dc.subject	Infecc ̧ões	en_US
dc.title	Efeitos Antimicrobianos Do Fentanil E Da Bupivacaína: Estudo İn Vitro	en_US
dc.type	Article	en_US