Human Papilloma Virus Frequency and Genotypes; Evaluation of the 4879 Screenings Made with Polymerase Chain Reaction and Chip Array Between 2001 and 2019 in Istanbul

Polat, Nedim; Vural, Gürcan

Human Papilloma Virus Frequency and Genotypes; Evaluation of the 4879 Screenings Made with Polymerase Chain Reaction and Chip Array Between 2001 and 2019 in Istanbul

dc.authorid	260723	en_US
dc.authorid	247456	en_US
dc.contributor.author	Polat, Nedim
dc.contributor.author	Vural, Gürcan
dc.date.accessioned	2021-09-06T13:08:53Z
dc.date.available	2021-09-06T13:08:53Z
dc.date.issued	2021
dc.department	İstanbul Beykent Üniversitesi	en_US
dc.description.abstract	Objectives: The aim of this study is the documentation of human papilloma virus (HPV) frequency and types seen in the city of Istanbul, Turkey, as well as evaluation of the relationship between these subtypes and cytological and pathological diagnoses. Methods: 4879 cases were studied in our molecular pathology department between 2001 and 2019 in Istanbul. Between 2001 and 2010, 1692 cases were screened for HPV 6, 11, 16, 18, 31, and 33 by conventional hybridization and polymerase chain reaction (PCR). Since 2011, up to 49 HPV typing has been performed for 3187 cases with chip array. The cases were referred to the pathology center and the hospital pathology department by clinicians for screening before HPV vaccination and on the observation of precancerous changes and koilocyts in cytological-histopathological evaluations. Results: In this study, the frequency of HPV was found to be 10.8% (527 HPV-positive cases). Among these, 348 cases were high-risk groups, whether or not they were previously associated with a low-risk group. When we look at the distribution of the cases according to the high-risk HPV types, HPV 16 is the most common type. The frequencies of occurrence of other HPV types are as following: HPV-16: 41.7%, HPV-31: 11.7%, HPV-52: 7.9%, HPV-51: 7.1%, HPV-33: 6.9%, HPV-45: 6.5%, HPV-18: 6.3%, HPV-39: 6.1%, and HPV-58: 5.8%. It was further found that multiple infections were 28% of high grade squamous intraepithelial lesion cases. HPV frequency was 38% and 72%, respectively, in cases with cytologically or histopathological precancerous, low-grade squamous intraepithelial lesion, and HSIL changes. As a final note, HPV was detected in 9 of 10 cases with cervical cancer (90%). Only 1 adenocarcinoma case detected in the series was a double infection with HPV types 18 and 45. Conclusion: HPV 16 was the most common type found in this study. It is followed by types 31, 52, 51, 33, 45, 18, 39, and 58, respectively. The most common association observed in double infections was between HPV 16 and 58. It was also observed that the incidence of HPV in the city of Istanbul, Turkey, was similar to other developed countries. As a final note, in addition to screening tests, PCR and chip array studies should be conducted and the community should be informed about preventive medicine and the importance of condom use.	en_US
dc.identifier.citation	Med Bull Sisli Etfal Hosp 2021;55(2):232–236	en_US
dc.identifier.doi	10.14744/SEMB.2021.67355
dc.identifier.issn	1126-6708
dc.identifier.pmid	34349601	en_US
dc.identifier.trdizinid	533426	en_US
dc.identifier.uri	https://search.trdizin.gov.tr/yayin/detay/533426
dc.identifier.uri	https://doi.org/10.14744/SEMB.2021.67355
dc.identifier.wos	WOS:000669998900015	en_US
dc.identifier.wosquality	N/A	en_US
dc.indekslendigikaynak	Web of Science	en_US
dc.indekslendigikaynak	TR-Dizin	en_US
dc.indekslendigikaynak	PubMed	en_US
dc.language.iso	en	en_US
dc.publisher	Kare Publishing	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı	en_US
dc.subject	Cervical cancer	en_US
dc.subject	Chip array	en_US
dc.subject	Epidemiology	en_US
dc.subject	Genotype	en_US
dc.subject	Human papilloma virus	en_US
dc.subject	Polymerase chain reaction	en_US
dc.title	Human Papilloma Virus Frequency and Genotypes; Evaluation of the 4879 Screenings Made with Polymerase Chain Reaction and Chip Array Between 2001 and 2019 in Istanbul	en_US
dc.type	Article	en_US