Association Between Human Leukocyte Antigen Gene Polymorphisms And Multiple Epıya-C Repeats İn Gastrointestinal Disorders

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dc.authorid243533en_US
dc.authorid49539en_US
dc.authorid50053en_US
dc.authorid256465en_US
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorDemiryas, Süleyman
dc.contributor.authorYılmaz, Erkan
dc.contributor.authorUysal, Ömer
dc.contributor.authorKepil, Nuray
dc.contributor.author., ve diğer.
dc.date.accessioned2020-10-16T11:49:20Z
dc.date.available2020-10-16T11:49:20Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.descriptionPubmed'de indekslidir.en_US
dc.description.abstractBackground: Polymorphisms of human leukocyte antigen (HLA) genes are suggested to increase the risk of gastric cancer (GC). Aim: To investigate the HLA allele frequencies of patients with GC relative to a control group in terms of CagA+ multiple (? 2) EPIYA-C repeats. Methods: The patient group comprised 94 patients [44 GC and 50 duodenal ulcer (DU) patients], and the control group comprised 86 individuals [(50 non-ulcer dyspepsia patients and 36 people with asymptomatic Helicobacter pylori (H. pylori)]. Polymerase chain reaction was performed for the amplification of the H. pylori cagA gene and typing of EPIYA motifs. HLA sequence-specific oligonucleotide (SSO) typing was performed using Lifecodes SSO typing kits (HLA-A, HLA-B HLA-C, HLA-DRB1, and HLA-DQA1-B1 kits). Results: The comparison of GC cases in terms of CagA+ multiple (? 2) EPIYA-C repeats showed that only the HLA-DQB1*06 allele [odds ratio (OR): 0.37, P = 0.036] was significantly lower, but significance was lost after correction (Pc = 0.1845). The HLA-DQA1*01 allele had a high ratio in GC cases with multiple EPIYA-C repeats, but this was not significant in the univariate analysis. We compared allele frequencies in the DU cases alone and in GC and DU cases together using the same criterion, and none of the HLA alleles were significantly associated with GC or DU. Also, none of the alleles were detected as independent risk factors after the multivariate analysis. On the other hand, in a multivariate logistic regression with no discriminative criterion, HLA-DQA1*01 (OR = 1.848), HLA-DQB1*06 (OR = 1.821) and HLA-A*02 (OR = 1.579) alleles were detected as independent risk factors for GC and DU. Conclusion: None of the HLA alleles were detected as independent risk factors in terms of CagA+ multiple EPIYA-C repeats. However, HLA-DQA1*01, HLA-DQB1*0601, and HLA-A*2 were independent risk factors with no criterion in the multivariate analysis. We suggest that the association of these alleles with gastric malignancies is not specifically related to cagA and multiple EPIYA C repeats.en_US
dc.identifier.citationWorld J Gastroenterol 2020 August 28; 26(32): 4817-4832en_US
dc.identifier.doi10.3748/wjg.v26.i32.4817.
dc.identifier.issn2450-8608
dc.identifier.pmid32921959en_US
dc.identifier.scopus2-s2.0-85090873257en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v26.i32.4817.
dc.identifier.wosWOS:000568827500007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectCagAen_US
dc.subjectDuodenal ulceren_US
dc.subjectEPIYAen_US
dc.subjectGastric canceren_US
dc.subjectHelicobacter pylorien_US
dc.subjectHuman leukocyte antigenen_US
dc.titleAssociation Between Human Leukocyte Antigen Gene Polymorphisms And Multiple Epıya-C Repeats İn Gastrointestinal Disordersen_US
dc.typeArticleen_US

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