Relationships Among Oncostatin M, İnsulin Resistance, And Chronic İnflammation: A Pilot Study

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dc.authorid252295en_US
dc.contributor.authorErdem, Mahmut Genco
dc.contributor.authorAkarsu, Murat
dc.contributor.authorHursçitoglu, Mehmet
dc.contributor.authorToprak, Zeki
dc.contributor.authorYoldemir, Sengül Aydin
dc.contributor.authorAltun, Özgür
dc.contributor.authorToprak, Ilkim Deniz
dc.contributor.authorÖzcan, Mustafa
dc.contributor.authorYürüyen, Gülden
dc.contributor.authorUğurlukişi, Bilal
dc.contributor.author., ve diğer.
dc.date.accessioned2021-04-20T08:31:28Z
dc.date.available2021-04-20T08:31:28Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective: Activated macrophages (M1-type macrophages) in adipose tissue secrete many proinflammatory cytokines that induce insulin resistance (IR). Oncostatin M (OSM), a member of the interleukin-6 (IL-6) family of Gp130 cytokines, plays an important role in a variety of biological functions, including the regulation of inflammatory responses. Proinflammatory cytokines released in patients with IR trigger a chronic, low-grade inflammatory reaction in blood vessel walls. This inflammator response leads to endothelial damage, which is the main mechanism for atherosclerosis and many cardiovascular diseases. Animal studies have reported a relationship between OSM and IR. To the best of our knowledge, however, few clinical studies have examined this topic. Therefore, we studied the relationship between serum levels of OSM and IR. Subjects and methods: This prospective cross-sectional case-control study enrolled 50 people with IR (according to the HOMA-IR and QUICKI indices) and 34 healthy controls. The fasting blood concentrations of insulin, glucose, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, total cholesterol, C-reactive protein (CRP), and OSM were determined. Results: There were no significant differences between the two groups in age, sex, and HbA1c levels. Univariate analyses showed that waist circumference (WC) and levels of fasting glucose, insulin, CRP, HDL-C, OSM, HOMA-IR, and QUICKI differed between the two study groups. In multivariate analyses, both IR indices (QUICKI and HOMA) and OSM differed between the two groups. Conclusion: OSM was correlated with the IR indices (QUICKI and HOMA). For simplicity, it might replace the other IR indices in the future. Further detailed studies are needed to confirm this.en_US
dc.identifier.citationArch Endocrinol Metab . 2021 Apr 5;65(2):253.en_US
dc.identifier.doi10.20945/2359-3997000000357
dc.identifier.issn1305-5577
dc.identifier.pmid33826839en_US
dc.identifier.urihttps://doi.org/10.20945/2359-3997000000357
dc.identifier.wosWOS:000642426200016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSciELOen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectDiabetes mellitusen_US
dc.subjectİnsulin resistanceen_US
dc.subjectOncostatin Men_US
dc.subjectMetabolic syndromeen_US
dc.titleRelationships Among Oncostatin M, İnsulin Resistance, And Chronic İnflammation: A Pilot Studyen_US
dc.typeArticleen_US

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