Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis

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dc.contributor.authorTekin, Tuba Ozkan
dc.contributor.authorKaris, Denizhan
dc.contributor.authorAlkan, Fatma Ates
dc.contributor.authorCetin, Guven
dc.contributor.authorErcan, Alev Meltem
dc.date.accessioned2024-03-13T10:35:01Z
dc.date.available2024-03-13T10:35:01Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: Trace elements (TE) are vital for cellular mechanisms at biological, chemical and molecular levels. The effects of TE in diagnosis, progression and treatment of essential thrombocytosis (ET), which is one of the chronic myeloproliferative neoplasms is a rare clonal stem cell disease characterized by increased thrombocyte numbers with impaired function, have not been elucidated in detail yet. The aim of the present study was to investigate the effects of TE alterations in an ET model and the efficacy of TE in ET treatment protocol by means of a vast number of TE.Methods: Study groups were categorized as patients with ET diagnosis (ET group, n:30), patients with reactive thrombocytosis secondary to iron deficiency anemia (IDA-RT) (IDA-RT group, n:30) and healthy controls (HC group, n:30). Serum levels of copper (Cu), iron (Fe), cobalt (Co), chromium (Cr), aluminum (Al), silicon (Si), nickel (Ni), zinc (Zn), selenium (Se), manganese (Mn), boron (B) and magnesium (Mg) were analyzed utilizing inductively coupled plasma-optical emission spectrophotometer instrument (ICP-OES). Statistical analysis was evaluated using SPSS 23.0.Results: ET group had statistically higher serum levels of Co and Mg (p < 0.05), Ni and Mn (p < 0.001), and lower Si (p < 0.05) than IDA-RT group. ET group had statistically higher serum levels of Co and Mn (p < 0.05), and Ni (p < 0.001), and lower Al, Si and Se (p < 0.001) than HC group. Serum levels of Fe, Al and Se (p < 0.001), and Mg (p < 0.01), and Zn (p < 0.05) in IDA-RT group were significantly lower than HC group.Conclusion: This novel study pointed out that alterations of many serum TE by means of both increment or decrement might have close relationship with mechanisms and complications of ET onset and follow-up. We consider that further research of TE would elucidate ethiopathogenesis and prognosis of ET. Thus, analysis of serum trace elements in essential thrombocytosis patients may be an important protocol by means of diagnosis, treatment and follow-up intervals.en_US
dc.description.sponsorship[INHS-2020]; [22 - 23]en_US
dc.description.sponsorshipAcknowledgements This study was presented as oral presentation at INSAC Natural and Health Sciences (INHS-2020) , 22 - 23 May 2020.en_US
dc.identifier.doi10.1016/j.jtemb.2022.127034
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid35839560en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2022.127034
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4215
dc.identifier.volume73en_US
dc.identifier.wosWOS:000829373200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofJournal Of Trace Elements In Medicine And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEssential thrombocytosisen_US
dc.subjectReactive thrombocytosisen_US
dc.subjectTrace elementsen_US
dc.titleEvaluation of trace elements in essential thrombocytosis and reactive thrombocytosisen_US
dc.typeArticleen_US

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