Investigation of the Effects of MicroRNA-221 Expression Levels in Glioblastoma Multiforme Tumors

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dc.contributor.authorOzdogan, Selcuk
dc.contributor.authorYaltirik, Cumhur Kaan
dc.contributor.authorYilmaz, Seda Gulec
dc.contributor.authorAkdeniz, Fatma Tuba
dc.contributor.authorSumerkent, Kadir
dc.contributor.authorDuzkalir, Ali Haluk
dc.contributor.authorTure, Ugur
dc.date.accessioned2024-03-13T10:33:08Z
dc.date.available2024-03-13T10:33:08Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground/Aim: The aim of our study was to examine miRNA-221 as a candidate biomarker to define prognosis and/or classification for glial tumors. Materials and Methods: This study included 39 patients who underwent glial tumor surgery and 40 healthy individuals as the control group. miRNA expression levels were determined by real-time polymerase chain reaction (RT-PCR). Receiver operating characteristic curve analysis was used for analyzing the predictive ability of miRNA-221. Results: The levels of miRNA-221 expression were determined by comparing the Delta CT values of miRNAs and the internal control. When the expression levels of miRNA-221 were compared according to the Delta CT method, miRNA-221 was found to be significantly increased in the patient group compared to the control group (p<0.0001). Conclusion: Increased expression levels of miRNA-221 could be a biomarker for glial tumors.en_US
dc.identifier.doi10.21873/anticanres.14308
dc.identifier.endpage3270en_US
dc.identifier.issn0250-7005
dc.identifier.issn1791-7530
dc.identifier.issue6en_US
dc.identifier.pmid32487621en_US
dc.identifier.scopus2-s2.0-85085909824en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3265en_US
dc.identifier.urihttps://doi.org/10.21873/anticanres.14308
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3795
dc.identifier.volume40en_US
dc.identifier.wosWOS:000538104800027en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Inst Anticancer Researchen_US
dc.relation.ispartofAnticancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlial tumorsen_US
dc.subjectglioblastomaen_US
dc.subjectmicroRNAen_US
dc.subjectmiRNA-221en_US
dc.subjectbiomarkeren_US
dc.titleInvestigation of the Effects of MicroRNA-221 Expression Levels in Glioblastoma Multiforme Tumorsen_US
dc.typeArticleen_US

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