Investigation of the Effects of MicroRNA-221 Expression Levels in Glioblastoma Multiforme Tumors

Küçük Resim Yok

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Int Inst Anticancer Research

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Background/Aim: The aim of our study was to examine miRNA-221 as a candidate biomarker to define prognosis and/or classification for glial tumors. Materials and Methods: This study included 39 patients who underwent glial tumor surgery and 40 healthy individuals as the control group. miRNA expression levels were determined by real-time polymerase chain reaction (RT-PCR). Receiver operating characteristic curve analysis was used for analyzing the predictive ability of miRNA-221. Results: The levels of miRNA-221 expression were determined by comparing the Delta CT values of miRNAs and the internal control. When the expression levels of miRNA-221 were compared according to the Delta CT method, miRNA-221 was found to be significantly increased in the patient group compared to the control group (p<0.0001). Conclusion: Increased expression levels of miRNA-221 could be a biomarker for glial tumors.

Açıklama

Anahtar Kelimeler

Glial tumors, glioblastoma, microRNA, miRNA-221, biomarker

Kaynak

Anticancer Research

WoS Q Değeri

Q4

Scopus Q Değeri

Q2

Cilt

40

Sayı

6

Künye