Evaluation of Antioxidant Capacity, Anticholinergic and Antidiabetic Activities, and Phenolic Ingredients of Asphodelus aestivus by LC-MS/MS

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dc.contributor.authorKose, Leyla Polat
dc.date.accessioned2024-03-13T10:30:35Z
dc.date.available2024-03-13T10:30:35Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractHerein, it was aimed to evaluate three different extracts of the plant Asphodelus aestivus in terms of their antioxidant capacity, total phenolic content, flavonoid profile, and anticholinergic and antidiabetic activity. In addition, the phenolic content of the A. aestivus extracts was determined by liquid chromatography-mass spectrometry/mass spectrometry. The results obtained in the antioxidant studies were checked against butylated hydroxyanisole, butylated hydroxytoluene, Trolox, and alpha-tocopherol antioxidants, which are reference standards. The half-maximal inhibition concentration (IC50) values of A. aestivus for 1,1-diphenyl-2-picryl-hydrazyl and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) removal activity were 245.015-285.851 and 285.818-371.563 mu g/mL, respectively. Then, the reducing impact of A. aestivus extracts was evaluated by the cupric ion (Cu2+), ferric ion (Fe3+), and Fe3+-TPTZ reducing capabilities. Moreover, 0.058, 0.064, and 0.100 mu g of gallic acid equivalent of phenolic and 0.500, 1.212, and 2.074 mu g of quercetin equivalent of flavonoid contents were determined from 1 mg of ethanol, water, and water-ethanol extracts, respectively. For water-ethanol, ethanol, and water extracts of A. aestivus, IC50 values of 0.062 +/- 0.0001, 0.068 +/- 0.0002, and 0.090 +/- 0.0001 mu g/mL against acetylcholinesterase, respectively, were calculated. In addition, against the enzyme alpha-glucosidase IC50 values of 16.376 +/- 0.2216, 18.907 +/- 0.3004, and 24.471 +/- 0.4929 mu g/mL, respectively, were calculated. Extracts showed considerable biological activities thanks to the important molecules they contain.en_US
dc.identifier.doi10.1002/cbdv.202301965
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid38237081en_US
dc.identifier.scopus2-s2.0-85184707803en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202301965
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3439
dc.identifier.wosWOS:001161593000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsphodelus aestivusen_US
dc.subjectAntioxidant activityen_US
dc.subjectPhenolic contentsen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectalpha-glucosidaseen_US
dc.titleEvaluation of Antioxidant Capacity, Anticholinergic and Antidiabetic Activities, and Phenolic Ingredients of Asphodelus aestivus by LC-MS/MSen_US
dc.typeArticleen_US

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