Predictors of High-Grade Residual Disease After Repeat Conization in Patients with Positive Surgical Margins

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dc.authorid176142en_US
dc.contributor.authorSalihoğlu, Mehmet Yavuz
dc.contributor.authorvd.
dc.date.accessioned2023-03-14T05:30:27Z
dc.date.available2023-03-14T05:30:27Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjectives: No consensus exists on the subsequent management strategy of patients who exhibit positive surgical margin (PSM) after re-excision of high-grade cervical intraepithelial neoplasia (CIN). The aim of the study is to examine the predictors related to the persistence of high-grade CIN lesions after re-excision, where PSM was left behind. Material and methods: The present retrospective study included patients with PSM who underwent repeated conization due to residual high-grade CIN lesions between January 2005 and December 2019. The SPSS software v20.0 was used for data interpretation and statistical analysis. P values less than 0.05 were accepted as statistically significant. Results: Repeat conization was performed in 91 patients, 43 (47.3%) presented with PSM with high-grade CIN, 6 (6.5%) presented with micro-invasive carcinoma, and 42 (46.2%) presented with clear surgical margin or CIN 1 at the surgical margin. At the time of conization, patients who presented with lesions > 5 mm in repeat cone specimens, exhibited a significantly higher rate of residual disease (p < 0.001). Besides, the involvement of the endocervical margin with high-grade CIN was the predictor of residual disease in repeat cone specimens (p = 0.006). Conclusions: In the cone specimen, the presence of lesion size greater than 5 mm and involvement of the endocervical margin were the predictors of high-grade residual disease after re-excision. Whether it is the first or second procedure, great care must be given to excise the lesion entirely at the time of the conization, preferably in one pieceen_US
dc.identifier.doi10.5603/GP.a2022.0019
dc.identifier.issn2076-3425
dc.identifier.pmid35894500en_US
dc.identifier.scopus2-s2.0-85145641393en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.5603/GP.a2022.0019
dc.identifier.wosWOS:000911118300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectCancer of the cervixen_US
dc.subjectCytology and GYN pathologyen_US
dc.subjectHPV infection and CINen_US
dc.titlePredictors of High-Grade Residual Disease After Repeat Conization in Patients with Positive Surgical Marginsen_US
dc.typeArticleen_US

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