Neonatal Outcomes of Critical Congenital Heart Defects: A Multicenter Epidemiological Study of Turkish Neonatal Society: Neonatal Outcomes of CCHD

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dc.contributor.authorDilli, Dilek
dc.contributor.authorAkduman, Hasan
dc.contributor.authorZenciroglu, Ayseguel
dc.contributor.authorCetinkaya, Merih
dc.contributor.authorOkur, Nilufer
dc.contributor.authorTuran, Ozden
dc.contributor.authorOzlu, Ferda
dc.date.accessioned2024-03-13T10:30:42Z
dc.date.available2024-03-13T10:30:42Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractCritical congenital heart disease (CCHD) is one of the leading causes of neonatal and infant mortality. We aimed to elucidate the epidemiology, spectrum, and outcome of neonatal CCHD in Turkiye. This was a multicenter epidemiological study of neonates with CCHD conducted from October 2021 to November 2022 at national tertiary health centers. Data from 488 neonatal CCHD patients from nine centers were entered into the Trials-Network online registry system during the study period. Transposition of great arteria was the most common neonatal CHD, accounting for 19.5% of all cases. Sixty-three (12.9%) patients had extra-cardiac congenital anomalies. A total of 325 patients underwent cardiac surgery. Aortic arch repair (29.5%), arterial switch (25.5%), and modified Blalock-Taussig shunt (13.2%). Overall, in-hospital mortality was 20.1% with postoperative mortality of 19.6%. Multivariate analysis showed that the need of prostaglandin E1 before intervention, higher VIS (> 17.5), the presence of major postoperative complications, and the need for early postoperative extracorporeal membrane oxygenation were the main risk factors for mortality. The mortality rate of CCHD in our country remains high, although it varies by health center. Further research needs to be conducted to determine long-term outcomes for this vulnerable population.en_US
dc.description.sponsorshipTurkish Neonatal Society (TNS)en_US
dc.description.sponsorshipThis study was supported by the Turkish Neonatal Society (TNS), which funded the online registration system used by the study (https:// www. trials- netwo rk. org/). The TNS had no role in the study design, data analysis, decision to publish, or preparation of the article. The corresponding author had full access to all the data in the study and took final responsibility for the decision to submit the manuscript for publication. The final version of the manuscript was approved by all authors. No honorarium, grant, or other form of funding was provided to any author in connection with the study.en_US
dc.identifier.doi10.1007/s00246-023-03362-z
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.pmid38153547en_US
dc.identifier.scopus2-s2.0-85180679995en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-023-03362-z
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3499
dc.identifier.wosWOS:001132064100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNewbornen_US
dc.subjectCritical congenital heart defectsen_US
dc.subjectEpidemiologyen_US
dc.subjectMortalityen_US
dc.subjectOutcomeen_US
dc.titleNeonatal Outcomes of Critical Congenital Heart Defects: A Multicenter Epidemiological Study of Turkish Neonatal Society: Neonatal Outcomes of CCHDen_US
dc.typeArticleen_US

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