Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds

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dc.authorid15560en_US
dc.authorid17755en_US
dc.authorid175976en_US
dc.authorid52535en_US
dc.authorid168497en_US
dc.contributor.authorTuyun, Amaç Fatih
dc.contributor.authorBayrak, Nilüfer
dc.contributor.authorYıldırım, Hatice
dc.contributor.authorOnul, Nihal
dc.contributor.authorMataracı Kara, Emel
dc.contributor.authorÖzbek Çelik, Berna
dc.date.accessioned2019-07-16T12:55:37Z
dc.date.available2019-07-16T12:55:37Z
dc.date.issued2015
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractA series of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) by the reaction of 2,3-dichloro-1,4-naphthoquinone with aryl amines (2a–h) and benzo[b]phenazine-6,11-dione derivatives (4a–c) by the treatment of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) with sodium azide were synthesized and tested for their in vitro antibacterial and antifungal activities. The results suggest that compounds 3d and 3g had potent antifungal activity against Candida albicans (MIC = 78.12??g/mL). All synthesized compounds (3a–h, 4a–c) possessed activity against E. faecalis with MIC values of between 312.5 and 1250??g/mL. Benzo[b]phenazine-6,11-dione derivatives (4a–c) were mostly active against Gram-positive bacteria. The structures of the new members of the series were established on the basis of their spectral properties (IR, 1H NMR, 13C NMR, and mass spectrometry).en_US
dc.identifier.doi10.1155/2015/645902
dc.identifier.issn2090-9063
dc.identifier.scopus2-s2.0-84936804195en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2015/645902
dc.identifier.wosWOS:000357811400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHindawitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.titleSynthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compoundsen_US
dc.typeArticleen_US

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