Presence Of Biofilm And Adhesin Genes İn Staphylococcus Aureus Strains Taken From Chronic Wound İnfections And Their Genotypic And Phenotypic Antimicrobial Sensitivity Patterns

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dc.authorid243533en_US
dc.authorid183728en_US
dc.authorid229975en_US
dc.authorid33481en_US
dc.authorid59869en_US
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorDemir, Cemil
dc.contributor.authorYiğin, Akın
dc.contributor.authorTokman, Hrisi Bahar
dc.contributor.authorYıldız, Songül Çetik
dc.date.accessioned2020-10-14T12:46:06Z
dc.date.available2020-10-14T12:46:06Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractThe purpose of this research was to examine biofilm (icaA, icaD and bap) and adhesin (clfA, fnbA, cna) genes, and also assess the genotypic and phenotypic antimicrobial resistance patterns of Staphylococcus aureus strains taken from wound specimens in Mardin, Turkey. A total of 220 wound specimens were investigated. The biofilm forming ability and resistance pattern for eleven antimicrobial agents were investigated by conventional and multiplex PCR methods. S. aureus were taken from 112 (50.9%) of 220 wound specimens. Moreover, biofilm production was found in 79 (70.5%) of the 112 S. aureus isolates. 97 (86.6%) strains of all isolates were positive for icaA and icaD, and 15 (13.4%) for bap. The adhesin genes, cna, fnbA and clfA were detected in 98 (87.5%), 87 (77.7%), and 75 (66.9%) strains, respectively. The numbers of MSSA and MRSA bearing antimicrobial resistance genes were 19 (16.96%) and 32 (28.57%) for blaZ, 9 (8.04%) and 17 (15.18%) for tetK, 6 (5.36%) and 14 (12.5%) for ermC, 2 (1.79%) and 7 (6.25%) for tetM, 0 (0%) and 5 (4.46%) for mecA, 2 (1.79%) and 4 (3.57%) for ermA, 1 (0.89%) and 2 (1.79%) for both tetK and tetM, respectively. Our findings indicate that multiplex PCR is a suitable way for identifying biofilm and adhesin producing S. aureus. Our data also provided a country-wide oversight of the S. aureus antimicrobial resistance gene profiles for the properly therapy of patients and to control the spreading of the resistance genes.en_US
dc.identifier.citationPhotodıagnosıs And Photodynamıc Therapy, 29 (101584), 2020en_US
dc.identifier.doi10.1016/j.pdpdt.2019.101584
dc.identifier.issn1748-0221
dc.identifier.pmid31689511en_US
dc.identifier.scopus2-s2.0-85074656127en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2019.101584
dc.identifier.wosWOS:000527929400066en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectBiofilm geneen_US
dc.subjectAdhesin geneen_US
dc.subjectWounden_US
dc.subjectInfectionen_US
dc.titlePresence Of Biofilm And Adhesin Genes İn Staphylococcus Aureus Strains Taken From Chronic Wound İnfections And Their Genotypic And Phenotypic Antimicrobial Sensitivity Patternsen_US
dc.typeArticleen_US

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