Correlation between high Choline metabolite signal in spectroscopy and sperm retrieval chance at micro-TESE

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dc.contributor.authorKarakuş, Cemil
dc.contributor.authorÖzyurt, R.
dc.date.accessioned2023-03-09T09:12:45Z
dc.date.available2023-03-09T09:12:45Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractOBJECTIVE: To determine the re lationship between choline (Cho) signal intensi ty measured before micro-dissection testicular sperm extraction (micro-TESE) and sperm re trieval rates in mTESE in non-obstructive azo ospermia (NOA) patients. PATIENTS AND METHODS: A total of 20 pa tients who underwent testicular MR spectros copy were included in the study. Participants consisted of 10 patients diagnosed with NOA and 10 fertile cases with normal sperm counts. Both groups of participants underwent bilater al testis MR spectroscopy. Ten patients in the NOA group underwent mTESE after spectros copy. The signal intensities of Cho, creatine (Cr), lactate, and lipids were analyzed and com pared with the results of fertile control. Cho sig nal intensity detected before mTESE in the NOA group and sperm retrieval rates were compared. RESULTS: Sperm was found in 5 of 10 patients who underwent mTESE. No sperm was found in five NOA cases. The main metabolites detected in NOA cases with sperm in mTESE were Cho and Cr. Cho and Cr signals were found to be signifi cantly lower in NOA cases where no sperm could be found in mTESE. Cho and Cr signal intensities of the fertile group were similar to NOA patients with sperm in mTESE but were significantly high er than those with NOA without sperm. While the cut-off value of Cho was 1.24 ppm (AUC 0.665, p = 0.01 [95% CI: 0.722–1.00]) the cut-off value of Cr was 1.18 ppm (AUC 0.887, p = 0.02 [95% CI]): 0.620–1.00]) for positive sperm retrieval. CONCLUSIONS: Detection of high Cho metab olite in the spectra before TESE in NOA patients increases sperm retrieval rates in mTESEen_US
dc.identifier.doi10.26355/eurrev_202202_28102
dc.identifier.issn2073-8994
dc.identifier.pmid35253167en_US
dc.identifier.scopus2-s2.0-85125806549en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202202_28102
dc.identifier.wosWOS:000763332500011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerducien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectNon-obstructive azoospermiaen_US
dc.subjectmTESEen_US
dc.subjectMR spectros copyen_US
dc.subjectCho signalen_US
dc.subjectSperm retrieval rateen_US
dc.titleCorrelation between high Choline metabolite signal in spectroscopy and sperm retrieval chance at micro-TESEen_US
dc.typeArticleen_US

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