A retrospective pilot study of hyperthermic intraperitoneal chemotherapy (HIPEC) using the closed CO2 recirculation system on peritoneal carcinomatosis

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dc.contributor.authorKarabay, Onder
dc.contributor.authorSerin, Kursat Rahmi
dc.contributor.authorHacim, Nadir Adnan
dc.contributor.authorSen, Fatma
dc.contributor.authorTerzi, Mustafa Cem
dc.date.accessioned2025-03-09T10:48:33Z
dc.date.available2025-03-09T10:48:33Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractBackground: Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) with a closed CO2 recirculation has been recently developed to amplify better distribution of chemotherapeutic drugs and adequate fluid circulation due to turbulent flow and increased intraabdominal pressure by CO2. In this study, we aimed to present clinicopathological features of patients with peritoneal carcinomatosis who underwent HIPEC with closed CO2 recirculation and the technical features of the technique. Methods: Twenty patients who underwent cytoreductive surgery for peritoneal carcinomatosis followed by the closed CO2 recirculation HIPEC between November 2018 and October 2019 were retrospectively analyzed. Demographic and clinical variables and treatment outcomes were recorded. Results: There were 11 (55%) female and nine (45%) male patients with a mean age of 57.6 +/- 10.3 years. Colon and ovarian cancer was the primary diagnosis in 10 (50%) and 4 patients (20%), respectively. The median peritoneal carcinomatosis index score was 15 (2-35). Colectomy and peritonectomy were the most common operations. During the early postoperative period, rate of minor and major complications were seen in six (30%) and three patients (15%), respectively. Median length of hospital stay and follow-up period were 6 days (4-15 days) and 7.5 months (2-17 months), respectively. There were three nonsurgical complications (pulmonary embolism, renal failure, myocardial infarction) leading to mortality in three patients (15%) during the follow-up period. Conclusions: HIPEC with CO2 recirculation may be a safe and feasible approach that can be performed in patients with peritoneal carcinomatosis secondary to different types of cancer.
dc.identifier.doi10.4103/ijc.IJC_584_20
dc.identifier.endpage529
dc.identifier.issn0019-509X
dc.identifier.issn1998-4774
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85214359093
dc.identifier.scopusqualityQ3
dc.identifier.startpage523
dc.identifier.urihttps://doi.org/10.4103/ijc.IJC_584_20
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4593
dc.identifier.volume61
dc.identifier.wosWOS:001391122100004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250310
dc.subjectCO2
dc.subjectcolorectal cancer
dc.subjectHIPEC
dc.subjectperitoneal carcinomatosis
dc.titleA retrospective pilot study of hyperthermic intraperitoneal chemotherapy (HIPEC) using the closed CO2 recirculation system on peritoneal carcinomatosis
dc.typeArticle

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