A retrospective pilot study of hyperthermic intraperitoneal chemotherapy (HIPEC) using the closed CO2 recirculation system on peritoneal carcinomatosis
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) with a closed CO2 recirculation has been recently developed to amplify better distribution of chemotherapeutic drugs and adequate fluid circulation due to turbulent flow and increased intraabdominal pressure by CO2. In this study, we aimed to present clinicopathological features of patients with peritoneal carcinomatosis who underwent HIPEC with closed CO2 recirculation and the technical features of the technique. Methods: Twenty patients who underwent cytoreductive surgery for peritoneal carcinomatosis followed by the closed CO2 recirculation HIPEC between November 2018 and October 2019 were retrospectively analyzed. Demographic and clinical variables and treatment outcomes were recorded. Results: There were 11 (55%) female and nine (45%) male patients with a mean age of 57.6 +/- 10.3 years. Colon and ovarian cancer was the primary diagnosis in 10 (50%) and 4 patients (20%), respectively. The median peritoneal carcinomatosis index score was 15 (2-35). Colectomy and peritonectomy were the most common operations. During the early postoperative period, rate of minor and major complications were seen in six (30%) and three patients (15%), respectively. Median length of hospital stay and follow-up period were 6 days (4-15 days) and 7.5 months (2-17 months), respectively. There were three nonsurgical complications (pulmonary embolism, renal failure, myocardial infarction) leading to mortality in three patients (15%) during the follow-up period. Conclusions: HIPEC with CO2 recirculation may be a safe and feasible approach that can be performed in patients with peritoneal carcinomatosis secondary to different types of cancer.
Açıklama
Anahtar Kelimeler
CO2, colorectal cancer, HIPEC, peritoneal carcinomatosis
Kaynak
Indian Journal of Cancer
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
61
Sayı
3
