Molecular Characterization And Antimicrobial Susceptibility Of Methicillin-Resistant Staphylococcus Aureus İsolates From Clinical Samples And Asymptomatic Nasal Carriers İn Istanbul (Turkey)

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dc.authorid243533en_US
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorDinçer, S.D
dc.contributor.authorNamal, N.
dc.contributor.authorCelepler, Y.
dc.contributor.authorAksaray, S.
dc.contributor.authorAktepe, O.C
dc.contributor.authorTorun, M.M
dc.date.accessioned2021-09-09T13:09:33Z
dc.date.available2021-09-09T13:09:33Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: Methicillin-resistant Staphylococcus aureus (MRSA) has been a widespread problem in Turkish hospitals. Aims: The aim of this study was to investigate the staphylococcal toxin genes of the clinical and nasal MRSA isolates, and their antibiotic resistance profiles. Materials and methods: Isolation of nasal and clinical bacteria was done following standard microbiological methods. The presence of antimicrobial resistance genes (mec A, pvl, tsst-1, and SEs genes) was determined using the real-time polymerase chain reaction (PCR) assay. Results: Among nasal MRSA isolates, 66.7% were toxigenic. The distribution of genes was as follows: pvl 26.7%, tsst-1 3.3%, and SEs 36.7%. Therefore, the nasal MRSA isolates had a rate of 23.3% multidrug resistance (MDR) pattern to the non-beta-lactams antibiotics. All (100%) clinical MRSA isolates were found to be toxigenic. The distribution of genes was as follows; pvl 10%, tsst-1 6.7%, and SEs 100%. The clinical MRSA isolates had a rate of 60% MDR. Conclusions: Following detection of pvl, tsst-1, and SEs among nasal and clinical MRSA isolates, and the presence of high antimicrobial resistance, the spread of these strains may be an additional factor contributing to the emergence of community-acquired (CA)-MRSA and hospital-acquired (HA)-MRSA. This study is the first to determine the resistance to linezolid and tigecycline in both nasal and clinical MRSA isolates, for the first time in Turkey. All nasal and clinical MRSA isolates were uniformly susceptible to vancomycin and quinupristin-dalfopristin. Our findings show that MRSA infections in Turkey can be empirically treated with vancomycin and quinupristin-dalfopristin based on the lack of demonstrable resistance to these drugs.en_US
dc.identifier.citationNiger J Clin Pract . 2021 Jul;24(7):997-1004en_US
dc.identifier.doi10.4103/njcp.njcp_615_19.
dc.identifier.issn0370-2693
dc.identifier.pmid34290175en_US
dc.identifier.scopus2-s2.0-85111739226en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_615_19.
dc.identifier.wosWOS:000678636700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedical and Dental Consultants' Association of Nigeriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectMRSAen_US
dc.subjectSEsen_US
dc.subjectmecAen_US
dc.subjectpvlen_US
dc.subjecttsst-1en_US
dc.titleMolecular Characterization And Antimicrobial Susceptibility Of Methicillin-Resistant Staphylococcus Aureus İsolates From Clinical Samples And Asymptomatic Nasal Carriers İn Istanbul (Turkey)en_US
dc.typeArticleen_US

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