Mosaic Human Preimplantation Embryos And Their Developmental Potential İn A Prospective, Non-Selection Clinical Trial

dc.authorid282485en_US
dc.contributor.authorFındıklı, Necati
dc.contributor.author.;, ve diğer
dc.date.accessioned2021-12-23T12:19:03Z
dc.date.available2021-12-23T12:19:03Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractChromosome imbalance (aneuploidy) is the major cause of pregnancy loss and congenital disorders in humans. Analyses of small biopsies from human embryos suggest that aneuploidy commonly originates during early divisions, resulting in mosaicism. However, the developmental potential of mosaic embryos remains unclear. We followed the distribution of aneuploid chromosomes across 73 unselected preimplantation embryos and 365 biopsies, sampled from four multifocal trophectoderm (TE) samples and the inner cell mass (ICM). When mosaicism impacted fewer than 50% of cells in one TE biopsy (low-medium mosaicism), only 1% of aneuploidies affected other portions of the embryo. A double-blinded prospective non-selection trial (NCT03673592) showed equivalent live-birth rates and miscarriage rates across 484 euploid, 282 low-grade mosaic, and 131 medium-grade mosaic embryos. No instances of mosaicism or uniparental disomy were detected in the ensuing pregnancies or newborns, and obstetrical and neonatal outcomes were similar between the study groups. Thus, low-medium mosaicism in the trophectoderm mostly arises after TE and ICM differentiation, and such embryos have equivalent developmental potential as fully euploid ones.en_US
dc.identifier.citationThe American Journal of Human Genetics108, 2238–2247, December 2, 2021en_US
dc.identifier.doi10.1016/j.ajhg.2021.11.002
dc.identifier.issn1029-8479
dc.identifier.pmid34798051en_US
dc.identifier.scopus2-s2.0-85119925819en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajhg.2021.11.002
dc.identifier.wosWOS:000727739200005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectCHROMOSOMAL MOSAICISMen_US
dc.subjectANEUPLOIDIESen_US
dc.subjectFERTILITYen_US
dc.titleMosaic Human Preimplantation Embryos And Their Developmental Potential İn A Prospective, Non-Selection Clinical Trialen_US
dc.typeArticleen_US

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