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Öğe Bilateral Foramen Mentale Lokalizasyonu ve Processus Condylaris Arası Uzunluğun Araştırılması(Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2018) Petekkaya, Emine; Kabakci, Ayse Gül; Ozandac, Sema; Balci, Raciha Sinem; Taskin, Rumeysa Gamze; Yucel, Ahmet HilmiAim: It was aimed to determine the localization of the foramen mentale in the study, to compare the obtained data with the national and international literature and to investigate the distance between the back of the processus condylaris. Material and Method: Thirty-one mandibula were measured in Çukurova University Faculty of Medicine Anatomy Department. In our study, the location of foramen mentale, distance of between foramen mentale and basis mandibula, the distance to the edge of the alveoli in the toothed and toothless chins and the distance between the back points of both processus condylaris with digital caliper (Torq brand 0-150 mm) were measured. After these measurements, minimum (min.), maximum (max.), mean and standard deviation (SS) values were obtained. Results: The distance between the back points of both processus condylaris; mean and SS, (min, max.) values were found as 106.291 ± 15.417 mm (84.54-168.00 mm), respectively. In the localization of the foramen mentale, the distance between the foramen mentale and the basal mandibula between the first and second premolar teeth, min, max, mean, and SS values were; 10.16 mm, 17.22 mm, 12.18 mm and 1.52 mm, respectively, while the distance between the foramen mentale and the basal mandibula in the lower second premolar teeth was; 9.88 mm, 20.86 mm, 13.83 mm and 2.12 mm, respectively. Min, max, mean, and SS values of the distance of between foramen mentale and alveolar edge of the mandibular teeth and toothless chins of the 1st and 2nd premolar teeth were 6.23 mm, 18.15 mm, 9.8 mm and 2.63 mm, while those of the lower second premolar teeth were 5.83 mm, 19.98 mm, 12.19 mm and 3.53 mm, respectively. Conclusion: We believe that we make measurements of mandibula will be useful in dental medicine surgical applications, anesthesia applications, plastic surgery and implant clinical applications.Öğe Correlation of metal ions with specific brain region volumes in neurodegenerative diseases(Tubitak Scientific & Technological Research Council Turkey, 2023) Melek, Ismet Murat; Kus, Berna; Kaptan, Zulal; Petekkaya, EmineBackground/aim: There are reports stating that deteriorations in metal homeostasis in neurodegenerative diseases promote abnormal protein accumulation. In this study, the serum metal levels in Alzheimer's disease (AD) and Parkinson's disease (PD) and its relationship with the cortical regions of the brain were investigated. Materials and methods: The patients were divided into 3 groups consisting of the AD group, PD group, and healthy control group (n = 15 for each). The volumes of specific brain regions were measured over the participants' 3 -dimensional magnetic resonance images, and they were compared across the groups. Copper, zinc, iron, and ferritin levels in the serums were determined, and their correlations with the brain region volumes were examined. Results: The volumes of left hippocampus and right substantia nigra were lower in the AD and PD groups, while the volume of the left nucleus caudatus (CdN) and bilateral insula were lower in the AD group compared to the control group. Serum zinc levels were lower in the AD and PD groups, while the iron level was lower in the PD group in comparison to the control group. In addition, the serum ferritin level was higher in the AD group than in the control group. Serum zinc and copper levels in the AD group were positively corre-lated with the volumes of the right entorhinal cortex, thalamus, CdN, and insula. Serum zinc and copper levels in the PD group showed a negative correlation with the left nucleus accumbens (NAc), right putamen, and right insula volumes. While the serum ferritin level in the PD group displayed a positive correlation with the bilateral CdN, putamen, and NAc, as well as the right hippocampus and insula volumes, no area was detected that showed a correlation with the serum ferritin level in the AD group. Conclusion: A relationship was determined between the serum metal levels in the AD and PD groups and certain brain cortical regions that showed volumetric changes, which can be important for the early diagnosis of neurodegenerative diseases.Öğe Effect of Chant Training on the Morphology of the Lateral Thyrohyoid Ligament: A Biometric and Acoustic Assessment(Mosby-Elsevier, 2019) Berdan, Meliha; Petekkaya, Emine; Yucel, Ahmet HilmiObjective. The purpose of this study was to determine the effects of chant training both on the morphologic structure of the lateral thyrohyoid ligament (LTL) and on the acoustic characteristics of the voice. Methods. Three groups of people participated in the study. Group I was new to chant training, group II had completed or was still continuing chant training, and group III, the control group, did not have any chant training. For all participants, laryngeal cervical magnetic resonance imaging was performed to measure the right and the left LTLs. Additionally, vocal acoustic analyses were performed and compared with the anatomic morphometric measurements. Appropriate statistical assessments were performed to evaluate the measurements. Results. The length of the LTL was greater in men, and this finding supports the gender-specific differences in laryngeal structures. Anatomic differences between groups showed that 8 months of training was not sufficient to trigger morphologic changes. The left and right LTLs were asymmetric, but this finding was not statistically significant. Conclusions. Analyses revealed that vocal training causes morphologic changes in anatomic structures, which affect vocal quality.Öğe Evaluation of the Golden Ratio in Nasal Conchae for Surgical Anatomy(SAGE, 2021) Petekkaya, Emine; Ulusoy, Mahinur; Bagheri, Hassan; Şanlı, Şükrü; Ceylan, Mehmet Seyit; Dokur, Mehmet; Karadağ, MehmetPurpose: The golden ratio is reached by the fractal model of the number sequence which is known as the ‘‘Fibonacci series’’ and has a convergent ratio of approximately 1.618 between 2 consecutive Fibonacci numbers. Golden ratio relationships have been shown in several plants in the nature and several organs and structures in the human body. The conchae, which form an important part of the nasal valve, have a special geometric significant in terms of providing turbulence to the laminar airflow that passes to the nasal cavity. Methods: This study made golden ratio calculations on 34 adults aged 20 to 45 years over computed tomography (CT) images. Totally, 34 volunteers (male, n ¼ 18 and female, n ¼ 16) with no nasal pathologies participated in the study. Using Adobe Photoshop, golden ratio calculations were made by applying the Fibonacci spiral on the images that best showed the conchae and meatuses on the CT images. Results: The intersection points of the spiral that was projected on the inferior and middle nasal concha were determined as S0, S1, S2, S3, and S4. The distances of S0-S1, S1-S2, S2-S3, and S3-S4 were measured. The concha measurements of the women showed significantly similar values to the golden ratio constant of *1.618 in the RS3/S4 and LS3/S4 measurements. Conclusion: We found that the S3/S4 region that captured the golden ratio in our study corresponds to the base part of the inferior nasal concha, and its place of spiraling in the nasal cavity is observed to have an important role in creating vorticesÖğe Evaluation of the Supraglottic and Subglottic Activities Including Acoustic Assessment of the Opera-Chant Singers(Mosby-Elsevier, 2019) Petekkaya, Emine; Yucel, Ahmet Hilmi; Surmelioglu, OzgurOpera and chant singers learn to effectively use aerodynamic components by breathing exercises during their education. Aerodynamic components, including subglottic air pressure and airflow, deteriorate in voice disorders. This study aimed to evaluate the changes in aerodynamic parameters and supraglottic structures of men and women with different vocal registers who are in an opera and chant education program. Vocal acoustic characteristics, aerodynamic components, and supraglottic structures were evaluated in 40 opera and chant art branch students. The majority of female students were sopranos, and the male students were baritone or tenor vocalists. The acoustic analyses revealed that the mean fundamental frequency was 152.33 Hz in the males and 218.77 Hz in the females. The estimated mean subglottal pressures were similar in females (14.99 cmH(2)O) and in males (14.48 cmH(2)O). Estimated mean airflow rates were also similar in both groups. The supraglottic structure compression analyses revealed partial anterior-posterior compressions in 2 tenors and 2 sopranos, and false vocal fold compression in 2 sopranos. Opera music is sung in high-pitched sounds. Attempts to sing high-pitched notes and frequently using register transitions overstrain the vocal structures. This intense muscular effort eventually traumatizes the vocal structures and causes supraglottic activity.Öğe An investigation of olfactory bulb and entorhinal cortex volumesin both patients with Alzheimer’s disease and healthy individuals,and a comparative analysis of neuropeptides(2020) Kaptan, Zülal; Burakgazi, Gülen; Ünalmış, Demet; Petekkaya, Emine; Kuş, Berna; Arpacı, Abdullah; Melek, İsmet MuratAlzheimer’s Disease (AD) is the most common neurodegenerative disease and is hard to diagnose at the early stages. The pathogenesis of AD is associated with the loss of a sense of smell. Reduction in the volumes of the Olfactory Bulb (OB) and Entorhinal Cortex (EC) is positively correlated with the decline of the smelling function where OB projects to EC. This study aims to detect the early changes in OB and EC volumes in AD patients by comparing them to healthy subjects. This study also aims to make a comparative analysis of plasma levels and the relationship between arginine-vasopressin (AVP) and Oxytocin (OT), which are neuropeptides associated with cognitive functions. The participants comprised 9 AD patients and 12 healthy individuals. We used volumetric methods such as MRICloud and IBASPM to measure the OB and EC volumes with the help of 3D MRI (Magnetic Resonance Imaging) images. We compared the left and right differentiation. Moreover, we investigated the neuropeptide levels in blood samples from the participants. We conducted a correlation analysis for all parameters. Bilateral OB atrophy was discovered in the AD patients in comparison to the control group (p=0.002 for right; p=0.015 for left). The right OB volume was measured to be larger than the left OB volume in the control group,but this asymmetry was not observed in the AD patients. The right and left EC's of the AD patients were atrophic in comparison to the control (p<0.001). The atrophy of the left EC was measured to be higher than that of the right EC (p=0.0008). There was no significant difference between the OT and AVP plasma levels of the AD patients and the control group. The study revealed that the OB and EC volumes of the AD patients were bilaterally reduced in comparison to patients of similar ages. This outcome may indicate that an MRI scan examination of OB and EC volumes may help early AD diagnosis.Öğe Media-Based Clinical Research On Selfie-Related İnjuries And Deaths(Ulusal Travma ve Acil Cerrahi Derneği, 2018) Petekkaya, Emine; Dokur, Mehmet; Karadağ, MehmetAMAÇ: Yoğun olarak özçekim ve bunları sosyal medyada paylaşmak ya da bununla ilişkili davranışlar, özellikle gençler arasında giderek artmaktadır. Bu durum özçekim nedenli travmalara yol açabilir. Bu klinik çalışmayı, özçekim ilişkili yaralanma ve ölümlere dikkat çekmek için gerçekleştirdik. GEREÇ VE YÖNTEM: Çalışmamızda medya kaynaklarında rapor edilen 111 özçekim olayı veya kazası ile ilişkili 159 olgu değerlendirildi. Özçekimle ilişkili yaralanma ve ölümlerin nedenleri ile birlikte kurbanların vital bulguları, demografileri, ritmisiteleri, tercihler, olay veya kaza tipleri, risk faktörleri ve etkilenen vücut bölgeleri değerlendirildi. BULGULAR: Özçekim kurbanlarının birçoğunun öğrenci olduğu belirlendi. Özçekim ilişkili yaralanma ve ölümler en sık Hindistan, ABD ve Rusya'dan bildirilmişti. Kurbanların en sık poz tercihi uçurum kenarı idi. En sık rapor edilen kaza tipi yüksekten zemine düşme idi. Özçekim ilişkili yaralanma ve ölümlerde en sık etkilenen çoklu vücut bölgesi idi. En sık saptanan ölüm nedeni multitravma ve suda boğulma idi. TARTIŞMA: Özçekim ilişkili yaralanma ve ölümler son yıllarda giderek artmaktadır. Özellikle ergenler ve genç yetişkinler tehlikeli özçekim açısından yüksek risk taşırlar. Bu nedenle özçekim ilişkili yaralanma ve ölümleri azaltmak için bilinçlendirme yapılmalıdır.Öğe The Most Cited Articles in Anatomy: An Update Study(2020) Petekkaya, EmineObjectives: In this bibliometric study, it has been aimed to conduct multi-dimensional citation analysis of the top100cited articles in anatomy field and to create an easy access for researchers in this dynamic field.Methods: The word "anatomy, which is used as a search term was written and queried into Thomson Reuter's 2019 Webof Science database to list all relevant articles in this field. The top 100 cited articles were analyzed by topic, journal,author, year, institution, level of evidence, adjusted citation index and also impact factor.Results: 135.275 eligible articles were found and we had chosen the top 100 cited, in the anatomy field, of these articlesby a bibliometric criteria. The mean citation number for the highly cited articles was 4.471 (range: 295-4471). The mostcited article on anatomy was “The brain’s default network: Anatomy, function, and relevance to disease” (4471 citations)conducted by Buckner RL et al. ‘’Ann N Y Acad Sci’’ journal made the biggest contribution to the top 100 list with 10articles whereas the most cited article originated from the Neuroimage. The country and year with most publicationswere the USA and 2003 respectively. Universtiy of London (n=13) and University College London (n=10) were the mostprolific institutions.Conclusion: Although anatomic-based studies are increasingly evolving towards neuroanatomy and neuroscience,anatomical morphology studies still important. However, it has been understood that more research is needed todetermine the forces that affect the direction of neuroanatomical research in new technology based neuroscienceand neuroimaging studies.Öğe The Most Cited Articles on ECMO: A Life-Saving Bibliometric Analysis(2020) Gunduz, Canan; Dokur, Mehmet Mümtaz; Koç, Suna; Petekkaya, EmineObjectives: Extracorporeal Membrane Oxygenation or ECMO, currently is a life-saving intervention in patients withsevere respiratory and cardiac failures. The aim of the present bibliometric study was to evaluate the characteristics ofthe most influential articles on ECMO.Methods: In the retrospective clinical study, the search term “ECMO” was queried into Thomson Reuter’s Web of Sciencedatabase between years 1975-2019 to list all the articles on this term. The top 100 cited articles were analyzed by topic,journal, author, year, institution, level of evidence, Adjusted Citation Index.Results: Out of screened 46.606 articles on ECMO, an analysis of the most cited articles among these results was performed. The analyzed articles had a median (IQR) 109 (82-1273) citation. Out of Top 100 cited articles, 58 of them hadmore than 100 citations. There was an increasing trend in number of publications on ECMO between years 2009-2014.In the Top 100cited articles list, 94 were clinical research studies, 5 were reviews and 1 article was an expert commiteereport. The majority of the clinical research articles were retrospective comparative clinical studies (n=37). The majorityof the articles were published in the Intensive Care Medicine (n=15) and was followed by Annals of Thoracic Surgery(n=11) and Circulation (n=7).Conclusion: Although ECMO currently is defined as an effective life supporting tool for patients with reversiblecardiac and pulmonary failure; there has been tremendous differences since the first use of ECMO in means of technology and indicated diseases as well as patient groups over time.Öğe Protective and therapeutic effects of milrinone on acoustic trauma in rat cochlea(Springer, 2019) Ceylan, Seyit Mehmet; Uysal, Erdal; Altinay, Serdar; Sezgin, Efe; Bilal, Nagihan; Petekkaya, Emine; Dokur, MehmetObjectiveThe aim of this study was to investigate the potential protective and therapeutic effects of milrinone, a specific phosphodiesterase (PDE) III inhibitor, on acoustic trauma-induced cochlear injury and apoptosis.MethodsA total number of 30 healthy Wistar albino rats were evenly divided into five groups as follows: group 1 was assigned as control group; group 2 and 3 were assigned as low-dosage groups (0.25mg/kg) in which milrinone was administered 1h before acoustic trauma (AT) and 2h after AT, respectively; group 4 and 5 were assigned as high-dosage groups (0.50mg/kg) in which the drug was administered 1h before AT and 2h after AT, respectively. Except control group, all treatment groups received a single dosage of milrinone for 5days. Distortion product otoacoustic emissions (DPOAE) measurements were recorded before AT as well as at second and fifth post-traumatic days. At the end of fifth day, all rats were sacrificed and the cochlea of the rats was removed for histopathological evaluation. In addition, the groups were compared in terms of apoptotic index via caspase-3 staining.ResultsIn terms of signal-to-noise ratio (SNR), there was no statistically significant difference among the groups following AT (p>0.05). After 5days of milrinone treatment, the best SNR values were found in group 5, though all groups did not statistically differ (p>0.05). In histopathological evaluation, vacuolization, inflammation, and edema scores in all treatment groups were statistically lower than those of the control group (p<0.05). In group 2 and 4 where the drug was administered before AT, the inflammation and apoptosis index was lower than those of group 3 and 5 where the drug was administered after AT (p<0.0001).ConclusionWe reveal that milrinone has a protective effect on cochlear damage in the experimental acoustic model of rats. This protective effect was more apparent following the pre-traumatic milrinone administration, and is associated with its effect on decreasing inflammation and apoptosis. Based on DPOAE measurements following AT, especially in the group 5 (high-dosage group), milrinone may also have a therapeutic effect.Öğe ŞARKICI VE ŞARKICI OLMAYAN BİREYLER ARASINDA SES ŞİDDETİ İLE AERODİNAMİK PARAMETRELERİN KARŞILAŞTIRMALI İNCELENMESİ(2019) Polat, Sema Özandaç; Petekkaya, Emine; Yücel, Ahmet HilmiSesin aerodinamik parametrelerinden subglottal basınç;fonasyon için aerodinamik itici bir güç iken ses şiddetiniarttırmada primer etkendir. Bu çalışmanın amacı şarkıcıbireyler ile şarkıcı olmayan bireyler arasında sesin aerodinamik parametreleri ile ses şiddet düzeyi arasındakiilişkiyi incelemektir. Çalışmaya 20 gönüllü ses eğitimialmış opera şan öğrencisi kadın-erkek ile ses eğitimialmamış 20 gönüllü kadın-erkek tıp fakültesi öğrencisikatıldı. Katılımcıların AeroviewPro PhonatoryAerodynamics System seti ile aerodinamik bileşenlerden subglottal hava basıncı, subglottal hava akımı ve sesbasınç düzeyi (sound pressure level/SPL) verileri belirlendi. Subglottal hava akımı ses eğitimi almamış öğrencilerde (1,96±0,54) opera şan öğrencilerinden(1,48±0,31) daha yüksek bulundu (P=0,005). Subglottalhava basıncı ise ses eğitimli grupta (14,36±2,99) seseğitimi almamış grup ortalamasından (11,32±3,47) daha yüksek değerler gösterdi (P=0,005). Ses şiddet düzeyi ortalaması ses eğitimi almış kişilerde (108,53 ± 3,48)ses eğitimi almamış kişilere oranla (101,43 ± 4,52) dahayüksek bulundu (P=0,001). Subglottal basınçtaki artışınses şiddetinde artışa yol açtığı verilerle doğrulanmıştır.Şarkı söylemek aerodinamik açıdan laryngeal yapılarınetkin kullanımını öğretmektedir.Öğe Şarkıcı Ve Şarkıcı Olmayan Bireyler Arasında Ses Şiddeti İle Aerodinamik Parametrelerin Karşılaştırmalı İncelenmesi(Erciyes Üniversitesi Sağlık Bilimleri Enstitüsü, 2019) Petekkaya, Emine; Polat, Sema Özandaç; Yücel, Ahmet HilmiSesin aerodinamik parametrelerinden subglottal basınç; fonasyon için aerodinamik itici bir güç iken ses şiddetini arttırmada primer etkendir. Bu çalışmanın amacı şarkıcı bireyler ile şarkıcı olmayan bireyler arasında sesin aerodinamik parametreleri ile ses şiddet düzeyi arasındaki ilişkiyi incelemektir. Çalışmaya 20 gönüllü ses eğitimi almış opera şan öğrencisi kadın-erkek ile ses eğitimi almamış 20 gönüllü kadın-erkek tıp fakültesi öğrencisi katıldı. Katılımcıların AeroviewPro Phonatory Aerodynamics System seti ile aerodinamik bileşenlerden subglottal hava basıncı, subglottal hava akımı ve ses basınç düzeyi (sound pressure level/SPL) verileri belirlendi. Subglottal hava akımı ses eğitimi almamış öğrencilerde (1,96±0,54) opera şan öğrencilerinden (1,48±0,31) daha yüksek bulundu (P=0,005). Subglottal hava basıncı ise ses eğitimli grupta (14,36±2,99) ses eğitimi almamış grup ortalamasından (11,32±3,47) daha yüksek değerler gösterdi (P=0,005). Ses şiddet düzeyi ortalaması ses eğitimi almış kişilerde (108,53 ± 3,48) ses eğitimi almamış kişilere oranla (101,43 ± 4,52) daha yüksek bulundu (P=0,001). Subglottal basınçtaki artışın ses şiddetinde artışa yol açtığı verilerle doğrulanmıştır. Şarkı söylemek aerodinamik açıdan laryngeal yapıların etkin kullanımını öğretmektedir.Öğe Yüz Tanıma Alanı (Gyrus Fusiformis): Betimleyici Bir İnceleme(Çukurova Üniversitesi Tıp Fakültesi, 2019) Petekkaya, Emine; Ulusoy, Mahinur; Kabakcı, Ayşe Gül; Yücel, Ahmet HilmiKişiler yüzleri ile tanınırlar. Bu nedenle yüzleri tanıma ve hatırlama yeteneği, insanın sosyal işlevselliği için çok önemlidir. Bu işlevler için, gyrus occipitalis inferior’da occipital yüz alanı, gyrus fusiformis’te fusiform yüz alanı ve sulcus temporalis superior'daki yüz ifade alanı gibi birbiriyle ilişkili beyin bölgeleri fonksiyon görmektedir.
