An association of the MCP-1 and CCR2 gene polymorphisms with oral lichen planus

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dc.contributor.authorOzturk, Ozgur
dc.contributor.authorCakmakoglu, Bedia
dc.contributor.authorOzturk, Gizem Nur
dc.contributor.authorUnur, Meral
dc.date.accessioned2024-03-13T10:35:08Z
dc.date.available2024-03-13T10:35:08Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective. The purpose of this study was to investigate the frequency of monocyte chemoattractant protein (MCP)-1 CCR2 gene Study Design. A cohort of 50 patients with OLP and 142 control participants without OLP were recruited to investigate the frequency of MCP-1 and CCR2 gene polymorphisms. Chi-square and Fisher's exact tests were used. Student t test and analysis of variance were used to compare demographic data between groups. Results. The MCP AA genotype was less common in the patient group (52%) than in the control group (66.2%; odds ratio [OR] = 0.553; 95% confidence interval [CI], 0.287-1.065; P = .075). The MCP G allele was higher in the patient group (48%) than in the control group (33.8%; OR = 1.808; 95% CI, 0.939-3.479; P= .075). The frequency of the MCP GG genotype was observed to be higher in the patient group (4%) than in the controls (0.7%; OR: 5.875, 95% CI:0.521-66,24; p = 0.106). The CCR2 64I64I genotype was more common in the patient group (6%) than in the control group (2.8%). All results were not statistically significant. Conclusion. We suggest that the G allele of MCP-1 and 64I64I genotype of CCR2 polymorphisms do not pose an increased risk for 2021;132:708-714)en_US
dc.description.sponsorshipIstanbul University scientific research project [9580]en_US
dc.description.sponsorshipThis project was supported by the Istanbul University scientific research project (BAP) budget (Project No. 9580).en_US
dc.identifier.doi10.1016/j.oooo.2021.06.009
dc.identifier.endpage714en_US
dc.identifier.issn2212-4403
dc.identifier.issn2212-4411
dc.identifier.issue6en_US
dc.identifier.pmid34511342en_US
dc.identifier.scopus2-s2.0-85114661477en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage708en_US
dc.identifier.urihttps://doi.org/10.1016/j.oooo.2021.06.009
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4252
dc.identifier.volume132en_US
dc.identifier.wosWOS:000728981100016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAn association of the MCP-1 and CCR2 gene polymorphisms with oral lichen planusen_US
dc.typeArticleen_US

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