Scaffold fabrication from drug loaded HNT reinforced polylactic acid by FDM for biomedical applications

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dc.contributor.authorKokcu, Ilknur
dc.contributor.authorEryildiz, Meltem
dc.contributor.authorAltan, Mirigul
dc.contributor.authorErtugrul, Melek Ipek
dc.contributor.authorOdabas, Sedat
dc.date.accessioned2024-03-13T10:30:39Z
dc.date.available2024-03-13T10:30:39Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIn this study, multifunctional polymer nanocomposite scaffolds were fabricated by the fused deposition method (FDM) for biomedical applications. First, halloysite nanotube reinforced (1-5 wt%) polylactic acid filaments were prepared by melt mixing process. For the selected compositions, HNT was loaded with metformin (MET) by electrostatic interactions. The characterization of the scaffolds was observed by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. The morphology of the nanocomposite scaffolds was investigated by scanning electron microscope. Mechanical behavior of the scaffolds was determined by tensile, compression, and three-point flexural tests. It has been seen that 3%wt of HNT loading showed 124%, 145%, and 41% increments in tensile, compression, and three-point flexural strength of the scaffolds, respectively. In-vitro drug release and cell viability of the scaffolds were also examined. According to the cell viability result, a better cell proliferation regimen was achieved in all HNT-containing groups without any cytotoxicity effect. Also, approximately 50% of the total drug was released from the scaffolds at the end of 120 h. Finally, it has been seen that the developed scaffolds show promise for bone regeneration and replacement of bone.en_US
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Unit; [FBA-2020-3895]en_US
dc.description.sponsorshipACKNOWLEDGMENT This work has been supported by Yildiz Technical University Scientific Research Projects Coordination Unit under project number FBA-2020-3895.en_US
dc.identifier.doi10.1002/pc.27231
dc.identifier.endpage2152en_US
dc.identifier.issn0272-8397
dc.identifier.issn1548-0569
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85146085139en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2138en_US
dc.identifier.urihttps://doi.org/10.1002/pc.27231
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3462
dc.identifier.volume44en_US
dc.identifier.wosWOS:000908695300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPolymer Compositesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdrug loadingen_US
dc.subjectFDMen_US
dc.subjecthalloysite nanotubeen_US
dc.subjectpolylactic aciden_US
dc.subjectscaffolden_US
dc.titleScaffold fabrication from drug loaded HNT reinforced polylactic acid by FDM for biomedical applicationsen_US
dc.typeArticleen_US

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