Dosimetric advantages of intensity-modulated proton therapy for oropharyngeal cancer compared with intensity-modulated radiation: A case-matched control analysis

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dc.contributor.authorHolliday, Emma B.
dc.contributor.authorKocak-Uzel, Esengul
dc.contributor.authorFeng, Lei
dc.contributor.authorThaker, Nikhil G.
dc.contributor.authorBlanchard, Pierre
dc.contributor.authorRosenthal, David I.
dc.contributor.authorGunn, G. Brandon
dc.date.accessioned2024-03-13T10:35:03Z
dc.date.available2024-03-13T10:35:03Z
dc.date.issued2016
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractA potential advantage of intensity-modulated proton therapy (IMPT) over intensity-modulated (photon) radiation therapy (IMRT) in the treatment of oropharyngeal carcinoma (OPC) is lower radiation dose to several critical structures involved in the development of nausea and vomiting, mucositis, and dysphagia. The purpose of this study was to quantify doses to critical structures for patients with OPC treated with IMPT and compare those with doses on IMRT plans generated for the same patients and with a matched cohort of patients actually treated with IMRT. In this study, 25 patients newly diagnosed with OPC were treated with IMPT between 2011 and 2012. Comparison IMRT plans were generated for these patients and for additional IMRT-treated controls extracted from a database of patients with OPC treated between 2000 and 2009. Cases were matched based on the following criteria, in order: unilateral vs bilateral therapy, tonsil vs base of tongue primary, T-category, N-category, concurrent chemotherapy, induction chemotherapy, smoking status, sex, and age. Results showed that the mean doses to the anterior and posterior oral cavity, hard palate, larynx, mandible, and esophagus were significantly lower with IMPT than with IMRT comparison plans generated for the same cohort, as were doses to several central nervous system structures involved in the nausea and vomiting response. Similar differences were found when comparing dose to organs at risks (OARs) between the IMPT cohort and the case-matched IMRT cohort. In conclusion, these findings suggest that patients with OPC treated with IMPT may experience fewer and less severe side effects during therapy. This may be the result of decreased beam path toxicities with IMPT due to lower doses to several dysphagia, odynophagia, and nausea and vomiting associated OARs. Further study is needed to evaluate differences in long-term disease control and chronic toxicity between patients with OPC treated with IMPT in comparison to those treated with IMRT. (C) 2016 American Association of Medical Dosimetrists.en_US
dc.identifier.doi10.1016/j.meddos.2016.01.002
dc.identifier.endpage194en_US
dc.identifier.issn0958-3947
dc.identifier.issn1873-4022
dc.identifier.issue3en_US
dc.identifier.pmid27158021en_US
dc.identifier.scopus2-s2.0-84964818567en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://doi.org/10.1016/j.meddos.2016.01.002
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4227
dc.identifier.volume41en_US
dc.identifier.wosWOS:000382185100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofMedical Dosimetryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProton radiotherapyen_US
dc.subjectIMPTen_US
dc.subjectOropharyngeal carcinomaen_US
dc.subjectDosimetric analysisen_US
dc.subjectAcute toxicityen_US
dc.titleDosimetric advantages of intensity-modulated proton therapy for oropharyngeal cancer compared with intensity-modulated radiation: A case-matched control analysisen_US
dc.typeArticleen_US

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