Hyperin attenuates cerulein-induced acute pancreatitis by regulating inflammation and oxidative stress

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dc.authorid0000-0003-2290-7255
dc.authorid0000-0001-6708-1229
dc.authorid0000-0001-7616-3330
dc.authorid0000-0001-6628-2109
dc.authorid0000-0003-1358-9224
dc.contributor.authorDuran, Yasin
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorPolat, Fatin Rüştü
dc.contributor.authorBıçakcı, Nurcan
dc.contributor.authorGündüz, İhsan
dc.contributor.authorBeyaz, Yüksel
dc.date.accessioned2026-11-03T09:25:37Z
dc.date.available2026-11-03T09:25:37Z
dc.date.issued23.10.2026
dc.departmentFakülteler, Tıp Fakültesi, Tıp Bölümü
dc.description.abstractAcute pancreatitis (AP) is a serious inflammatory condition of the pancreas often requiring hospitalisation and characterised by abdominal pain, nausea, and vomiting. Hyperin (HP), a natural flavonoid, possesses antioxidant and anti-inflammatory characteristics. However, the effect of HP on AP remains unclear. This study aimed to evaluate the protective effects of HP in a cerulein-induced AP model in rats, focusing on histopathological damage, inflammatory cytokines, and oxidative stress markers. All rats were randomly assigned into control (n = 8), AP (n = 8), and AP + HP (50 mg/kg) groups (n = 8). We created an AP rat model by intraperitoneal cerulein injections. We evaluated histopathologically pancreatic tissues using hematoxylin–eosin staining. NF-κB and TNF-α expressions were analysed using immunohistochemical method. Oxidative stress markers such as MDA, SOD, CAT, GPx as well as serum amylase and lipase levels were assessed using biochemical methods. IL-6 and IL-10 levels were measured using ELISA. HP treatment significantly reduced histological damage scores, including oedema, necrosis, and vacuolisation. Moreover, expression levels of NF-κB and TNF-α were markedly decreased in the AP + HP group. HP restored SOD activity and reduced MDA levels, indicating attenuated oxidative stress. HP decreased serum IL-6 and increased IL-10 levels, along with significant reductions in amylase and lipase. HP exerts both anti-inflammatory and antioxidant effects in cerulein-induced AP, primarily through NF-κB and TNF-α inhibition and SOD activation. These findings suggest that HP may be a promising natural compound for the adjunctive treatment of A
dc.identifier.citationDuran, Yasin, Karaboğa, İhsan, Okuyan, Hamza Malik, Polat, Fatin Rüştü, Bıçakcı, Nurcan, Gündüz, İhsan, Beyaz, Yüksel. (2026). Hyperin attenuates cerulein-induced acute pancreatitis by regulating inflammation and oxidative stress. Sprınger Nature.
dc.identifier.doi10.1007/s10735-025-10645-7
dc.identifier.urihttps://www.doi.org/10.1007/s10735-025-10645-7
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10903
dc.identifier.wosqualityQ4
dc.publisherSprınger Nature
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleHyperin attenuates cerulein-induced acute pancreatitis by regulating inflammation and oxidative stress

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