Inflammatory cytokines IL-6 and TNF- in patients with hip fracture

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dc.contributor.authorSaribal, D.
dc.contributor.authorHocaoglu-Emre, F. S.
dc.contributor.authorErdogan, S.
dc.contributor.authorBahtiyar, N.
dc.contributor.authorOkur, S. Caglar
dc.contributor.authorMert, M.
dc.date.accessioned2024-03-13T10:30:41Z
dc.date.available2024-03-13T10:30:41Z
dc.date.issued2019
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractThe SummaryMortality and remaining bedridden following the hip fracture surgery are not rare. We tried to measure the levels of inflammatory markers tumor necrosis factor-alpha (TNF-)and interleukin-6 (IL-6) following the hip fracture surgery and compare their levels with controls. We aimed to show a relationship between the levels of these markers and post-operative mortality and walking capability.IntroductionOsteoporosis is a condition, causing the hip fractures in the elderly. Hip fractures have a high rate of overall mortality up to 30% following the incident. Cytokines such as IL-6 and TNF- are suggested to play a role in bone resorption and, thus, in the etiology of osteoporosis.MethodsPlasma levels of IL-6 and TNF- were measured pre-operatively and on the first and second days after the surgery in 40 Turkish hip fracture patients. The levels of these cytokines were compared with 40 Turkish age-matched healthy controls. The levels of these cytokines were compared between the deceased and surviving patients, as well as the existence of walking capability following the surgery.ResultsSignificantly higher IL-6 levels were shown on the first and second days after the surgery (p=0.005; p=0.01, respectively). The overall death rate of our study group within the 2-year follow-up time was found to be 35%. No statistical significance was found in the means of 2-year follow-up mortality between the patients. Presence of walking capability did not differ between the patients, as well.ConclusionWe demonstrated an association between IL-6 levels and hip fracture in our study group following the surgery. We also suggest that TNF- and IL-6 levels are not related to the occurrence of death and walking capability after the surgery. However, these findings need further functional and clinical confirmation.en_US
dc.identifier.doi10.1007/s00198-019-04874-2
dc.identifier.endpage1031en_US
dc.identifier.issn0937-941X
dc.identifier.issn1433-2965
dc.identifier.issue5en_US
dc.identifier.pmid30701344en_US
dc.identifier.scopus2-s2.0-85065342480en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1025en_US
dc.identifier.urihttps://doi.org/10.1007/s00198-019-04874-2
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3497
dc.identifier.volume30en_US
dc.identifier.wosWOS:000467142400011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofOsteoporosis Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHip fractureen_US
dc.subjectTNF-en_US
dc.subjectIL-6en_US
dc.subjectCytokinesen_US
dc.subjectTumor necrosis factor-alphaen_US
dc.subjectInterleukin-6en_US
dc.titleInflammatory cytokines IL-6 and TNF- in patients with hip fractureen_US
dc.typeArticleen_US

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