Evaluation of the Antioxidant and Antiradical Properties of Some Phyto and Mammalian Lignans

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dc.authorid292052en_US
dc.authorid119165en_US
dc.contributor.authorKöse, Leyla Polat
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2021-12-23T12:21:35Z
dc.date.available2021-12-23T12:21:35Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIn this study, the antioxidant and antiradical properties of some phyto lignans (nordi-hydroguaiaretic acid, secoisolariciresinol, secoisolariciresinol diglycoside, and ?-(-)-conidendrin) and mammalian lignans (enterodiol and enterolactone) were examined by different antioxidant assays. For this purpose, radical scavenging activities of phyto and mammalian lignans were realized by 2,2?-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical (ABTS•+) scavenging assay and 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging assay. Additionally, the reducing ability of phyto and mammalian lignans were evaluated by cupric ions (Cu2+) reducing (CUPRAC) ability, and ferric ions (Fe3+) and [Fe3+-(TPTZ)2]3+ complex reducing (FRAP) abilities. Also, half maxi-mal inhibitory concentration (IC50) values were determined and reported for DPPH• and ABTS•+ scavenging influences of all of the lignan molecules. The absorbances of the lignans were found in the range of 0.150–2.320 for Fe3+ reducing, in the range of 0.040–2.090 for Cu2+ reducing, and in the range of 0.360–1.810 for the FRAP assay. On the other hand, the IC50 values of phyto and mammalian lignans were determined in the ranges of 6.601–932.167 µg/mL for DPPH• scavenging and 13.007–27.829 µg/mL for ABTS•+ scavenging. In all of the used bioanalytical methods, phyto lignans, as secondary metabolites in plants, demonstrated considerably higher antioxidant activity compared to that of mammalian lignans. In addition, it was observed that enterodiol and enterolac-tone exhibited relatively weaker antioxidant activities when compared to phyto lignans or standard antioxidants, including butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), Trolox, and ?-tocopherol.en_US
dc.identifier.citationMolecules 2021, 26(23), 7099en_US
dc.identifier.doi10.3390/molecules26237099
dc.identifier.issn2045-2322
dc.identifier.pmid34885681en_US
dc.identifier.scopus2-s2.0-85119991773en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/molecules26237099
dc.identifier.wosWOS:000741448100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectAntioxidant activityen_US
dc.subjectAntiradical activityen_US
dc.subjectLignanen_US
dc.subjectPhenolic compoundsen_US
dc.subjectReducing poweren_US
dc.titleEvaluation of the Antioxidant and Antiradical Properties of Some Phyto and Mammalian Lignansen_US
dc.typeArticleen_US

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