Determination of relationship between lipid peroxidation, antioxidant defence, trace elements, and hemorheology in COPD

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dc.contributor.authorSaribal, Devrim
dc.contributor.authorHocaoglu-Emre, Fatma Sinem
dc.contributor.authorAydemir, Birsen
dc.contributor.authorAkyolcu, Mehmet Can
dc.date.accessioned2024-03-13T10:33:27Z
dc.date.available2024-03-13T10:33:27Z
dc.date.issued2019
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground and objective: Oxidative stress has an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). There are studies suggesting a role of increased oxidative stress and decreased antioxidants in COPD patients. The aim of this study was to assess the levels of oxidative and anti-oxidant system elements, serum concentrations of trace elements, and blood viscosity in COPD patients. Materials and methods: Our study group consisted of 25 male patients with COPD, and 25 healthy non-smokers. The lipid peroxidation product malondialdehyde (MDA) and the anti-oxidant system elements superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were measured spectrophotometrically. Serum concentrations of copper (Cu), zinc (Zn), and iron (Fe) were determined using an atomic absorption spectrophotometer. Additionally, we measured blood viscosity using a viscosimeter. Results: Lipid peroxidation product MDA levels were found to be higher in plasma and erythrocytes. However GSH levels, SOD, and CAT enzyme activities were lower in erythrocytes of the patient group than in controls (p < 0.01). Fe and Zn levels were decreased, whereas Cu levels were increased in patient samples (p < 0.05. p < 0.01, respectively). There was no statistically significant difference between plasma and blood viscosities. Conclusion: The results of this study indicate that COPD leads to lipid peroxidation in the erythrocyte membrane and to decreased levels of anti-oxidant system elements. Serum trace element concentrations were found to be altered in COPD patients, suggesting their interaction with oxidant and anti-oxidant enzymes.en_US
dc.description.sponsorshipresearch council of Istanbul University, Cerrahpasa Medical Schoolen_US
dc.description.sponsorshipThe study was funded by the research council of Istanbul University, Cerrahpasa Medical School.en_US
dc.identifier.doi10.5414/TEX01567
dc.identifier.endpage136en_US
dc.identifier.issn0946-2104
dc.identifier.issue3en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.5414/TEX01567
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3946
dc.identifier.volume36en_US
dc.identifier.wosWOS:000470664000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofTrace Elements And Electrolytesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMDAen_US
dc.subjectSODen_US
dc.subjectcatalaseen_US
dc.subjectGSHen_US
dc.subjecttrace elementsen_US
dc.subjectCOPDen_US
dc.subjectoxidative stressen_US
dc.subjectviscosityen_US
dc.titleDetermination of relationship between lipid peroxidation, antioxidant defence, trace elements, and hemorheology in COPDen_US
dc.typeArticleen_US

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