Evaluation of the possible involvement of Ad-36-induced adipogenesis and coronary artery disease development in mediastinal adipose tissue samples

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dc.contributor.authorErgin S.
dc.contributor.authorTuran N.
dc.contributor.authorGode S.
dc.contributor.authorYilmaz H.
dc.contributor.authorSaribas S.
dc.contributor.authorDinc O.
dc.contributor.authorCizmecigil U.
dc.date.accessioned2024-03-13T10:01:24Z
dc.date.available2024-03-13T10:01:24Z
dc.date.issued2019
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractMediastinal fat has been suggested to be associated with cardiovascular diseases such as carotid stiffness, atherosclerosis and coronary artery calcification. We investigated the possible role of Ad-36-induced obesity in the pathogenesis of the coronary artery disease (CAD). Ad-36 DNA was investigated in the anterior mediastinal fat tissue samples of obese adults with CAD. Seventy-five obese adults with left main coronary artery (LMCA) disease, 28 non-obese adults with valvular heart diseases, and 48 healthy individuals without cardiovascular problems were included as the obese patient group (OPG), non-obese patient group (NOG) and healthy control group (HCG), respectively. We also simultaneously investigated Ad-36 antibodies by serum neutralization test (SNA), and measured leptin and adinopectin levels. Ad-36 antibodies were detected only in 10 patients (13.3%) within the 75 OPG. A statistically significant difference was detected between OPG, NOG and HCG in terms of Ad-36 antibody positivity (p<0.05). Ad-36 DNA was not detected in mediastinal tissue samples of OPG and NOP without PCR inhibitors. We suggest that Ad-36 may not have an affinity for mediastinal adipose tissue in obese patients with left main CAD and valvular heart diseases. Ad-36 antibody positivity results are not sufficient to reach a causal relationship. © 2019, EDIMES Edizioni Medico Scientifiche. All rights reserved.en_US
dc.description.sponsorshipBEK-2016-20167; Istanbul Üniversitesi; Firat University Scientific Research Projects Management Unit, FÃœBAP: 23874en_US
dc.description.sponsorshipThis research was supported by Scientific Research Projects Coordination Unit of Istanbul University. Project number: 23874. The poster presentation was supported financially by Istanbul University Research Fund with the project BEK-2016-20167. We also thank Esad Bonabi (Ay-din University, Turkey), Gulsel Ayaz (Istanbul University, Turkey) for their technical assistance related to the poster presentation in the 17th International Congress on Infectious Diseases (ICID) Hayderabad, 2016.en_US
dc.identifier.endpage298en_US
dc.identifier.issn1124-9390
dc.identifier.issue3en_US
dc.identifier.pmid31545773en_US
dc.identifier.scopus2-s2.0-85072561516en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3182
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEDIMES Edizioni Medico Scientificheen_US
dc.relation.ispartofInfezioni in Medicinaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenovirus-36en_US
dc.subjectLeft main coronary artery diseaseen_US
dc.subjectMediastinal faten_US
dc.subjectObesityen_US
dc.titleEvaluation of the possible involvement of Ad-36-induced adipogenesis and coronary artery disease development in mediastinal adipose tissue samplesen_US
dc.typeArticleen_US

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