A Retrospective Analysis of Anaerobic Bacteria Isolated in 236 Cases of Pleural Empyema and their Prevalance of Antimicrobial Resistance in Turkey

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dc.contributor.authorDemirci, Mehmet
dc.contributor.authorGemicioglu, Bilun
dc.contributor.authorSaribas, Suat
dc.contributor.authorHalis, Ayse N.
dc.contributor.authorTaner, Zeynep
dc.contributor.authorMamal-Torun, Muzeyyen
dc.contributor.authorKaratoka, Belma
dc.date.accessioned2024-03-13T10:33:29Z
dc.date.available2024-03-13T10:33:29Z
dc.date.issued2018
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: Parapneumonic effusions usually occur secondary to an infection and produce pus (empyema) that accumulates in the pleural space. We aimed to evaluate the prevalence of anerobes in patients with empyema and to assess their resistance patterns for seven antimicrobials. Methods: Pleural fluid specimens from 236 patients were inoculated on Schaedler agar. Anaerobic bacteria were identified via API 20 A. Susceptibility testing for penicillin, ampicillin + sulbactam, amoxicillin + clavulanate, cefoxitin, clindamycin, metronidazole, and imipenem were performed with the E-test. Results: There were 118 anaerobic bacterial strains detected in 66 (27.9%) of the 236 specimens. Gram-positive anaerobic cocci were detected in 54.23% and the predominant cocci were 41 Peptostreptococcus spp, (34.75%) followed by 17 P. acnes (14.41%) and 6 C. tertium (5.08%). The Gram-negative anaerobes were B. fragilis (28, 23.73%), P. melaninogenica (8, 6.78%), P. intermedia (4, 3.39%), F. nucleatum (6, 5.08%), F mortiferum (5, 4.24%), and P. asaccharolytica (3, 2.54%). All anaerobic strains were susceptible to ampicillin + sulbactam, amoxicillin + clavulanate, and imipenem. The highest MIC was found to be > 256 mu g/mL for penicillin in B. fragilis strains, 128 mu g/mL for cefoxitin in P. melaninogenica strains, 32 mu g/mL for clindamycin and 64 mu g/mL for metronidazole in P. acnes strains. Clindamycin resistance was detected in 46.6% B. fragilis, and 17.6% for P. acnes. Thirty-eight (32.2%) strains produced beta-lactamase. Conclusions: The use of antimicrobial agents for thoracic empyema should be based on the isolated pathogens and their resistance profiles. Clinicians should be aware of the wide diversity of anaerobic genera and species in cases of pleural empyema.en_US
dc.description.sponsorshipIstanbul University Research Found [BYP-900/19.012.006]en_US
dc.description.sponsorshipThis study was supported by Istanbul University Research Found. Project no BYP-900/19.012.006.en_US
dc.identifier.doi10.7754/Clin.Lab.2018.180317
dc.identifier.endpage1277en_US
dc.identifier.issn1433-6510
dc.identifier.issue7-8en_US
dc.identifier.pmid30146848en_US
dc.identifier.scopus2-s2.0-85052296393en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1269en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2018.180317
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3974
dc.identifier.volume64en_US
dc.identifier.wosWOS:000442664700022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanaerobic bacteriaen_US
dc.subjectpleural empyemaen_US
dc.subjectantimicrobial resistanceen_US
dc.titleA Retrospective Analysis of Anaerobic Bacteria Isolated in 236 Cases of Pleural Empyema and their Prevalance of Antimicrobial Resistance in Turkeyen_US
dc.typeArticleen_US

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