Trace Element Levels and Oxidant/Antioxidant Status in Patients with Alcohol Abuse

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dc.contributor.authorSaribal, Devrim
dc.contributor.authorHocaoglu-Emre, Fatma Sinem
dc.contributor.authorKaraman, Fulya
dc.contributor.authorMirsal, Hasan
dc.contributor.authorAkyolcu, Mehmet Can
dc.date.accessioned2024-03-13T10:30:52Z
dc.date.available2024-03-13T10:30:52Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractAlcohol abuse is a well-known cause of imbalance in trace element levels and oxidant/antioxidant status of individuals with long time consumption. However, the levels of these parameters in the patients on the early stages of alcohol dependence without liver damage differ on various studies. The aim of our study was to measure the levels of trace elements in the serum and oxidative/antioxidative system members in the red blood cells (RBC) of early-stage alcoholic individuals and compare with control subjects. Our study included 21 male patients recently hospitalized for alcohol abuse and 25 healthy non-abusing male controls. Levels of Fe, Zn, and Cu in the serum and MDA, SOD, CAT, and GSH in the red blood cells (RBC) of the subjects were measured. Fe, Zn, and Cu levels were lower in the study group when compared to the controls. Levels of lipid peroxidation marker MDA was high, whereas the activities of antioxidant enzymes SOD and CAT were decreased in our study group. However, levels of GSH, an antioxidant compound were higher in the alcohol abuse group. RBC SOD levels were positively correlated with Fe, Cu, Zn, and CAT. There was a positive correlation between Fe-Cu, Zn-Fe, Zn-Cu, CAT-Zn, and CAT-SOD. MDA was negatively correlated with Fe, Zn, SOD, and CAT. The results obtained from present study indicate that high levels of alcohol intake are related with increased oxidative damage and decreased levels of antioxidant enzymes and trace elements. Additionally, antioxidant compensation mechanisms are still on process in the early stages of chronic alcohol exposure.en_US
dc.identifier.doi10.1007/s12011-019-01681-y
dc.identifier.endpage13en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid30805875en_US
dc.identifier.scopus2-s2.0-85062150103en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-019-01681-y
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3573
dc.identifier.volume193en_US
dc.identifier.wosWOS:000511715800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrace elementsen_US
dc.subjectAlcohol abuseen_US
dc.subjectAlcoholismen_US
dc.subjectMDAen_US
dc.subjectSODen_US
dc.subjectCatalaseen_US
dc.subjectGSHen_US
dc.titleTrace Element Levels and Oxidant/Antioxidant Status in Patients with Alcohol Abuseen_US
dc.typeArticleen_US

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