Development of Chitosan and Silk Fibroin Nanofibers Incorporated With ZnO and TiO2 Nanoparticles for Wound Dressing Applications

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dc.authorid0000-0002-5572-7966
dc.authorid0000-0002-0342-2060
dc.contributor.authorTosyali, Ozlem Ayse
dc.contributor.authorEsenturk-Guzel, Imren
dc.contributor.authorIzbudak, Burcin
dc.contributor.authorAbdo, Luceyn
dc.contributor.authorBal-Ozturk, Ayca
dc.contributor.authorOzkanca, Cemre
dc.contributor.authorDosler, Sibel
dc.date.accessioned2026-01-31T15:07:22Z
dc.date.available2026-01-31T15:07:22Z
dc.date.issued2026
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractWound infections remain a significant challenge, often complicating the healing process. Consequently, there is a growing need for innovative alternatives to conventional treatment strategies. In recent years, electrospun nanofibers (NFs) made from natural or synthetic polymers have gained popularity as wound dressing materials due to their structural similarity to the extracellular matrix and ability to incorporate bioactive agents. This study aimed to develop multifunctional wound dressings by incorporating zinc oxide nanoparticles (ZnO NPs) and titanium dioxide nanoparticles (TiO2 NPs) separately into polymeric NFs made of chitosan (CS), silk fibroin (SF), and polyethylene oxide (PEO). The NFs were fabricated using the electrospinning technique, and three formulations were prepared: plain CS/SF NFs, CS/SF/ZnO NFs, and CS/SF/TiO2 NFs. These were systematically characterized and compared in terms of their physicochemical, mechanical, and biological properties to evaluate their potential for wound dressing applications. The chemical composition, thermal stability, morphology, and mechanical properties of the prepared NFs were evaluated using FTIR, TGA, SEM, and tensile strength tests, respectively. FTIR analysis confirmed the successful integration of the polymers and nanoparticles. The addition of ZnO and TiO2 NPs improved the thermal stability and mechanical strength of the NFs. SEM images revealed that all NFs exhibited long, continuous, and bead-free morphologies. Additionally, the swelling ratio, degradation behavior, and water vapor transmission rate (WVTR) were assessed. Swelling studies indicated a high water absorption capacity with pH-dependent behavior, especially under acidic conditions. Biodegradation tests showed a slower degradation rate in the NFs containing NPs. The WVTR results confirmed that all NF formulations are suitable for maintaining an optimal moisture environment for wound healing. Cell viability assays demonstrated good biocompatibility, while antimicrobial studies revealed strong bactericidal activity in CS/SF/ZnO NFs. In contrast, CS/SF/TiO2 NFs exhibited limited antimicrobial activity in the absence of UV light. Overall, the findings suggest that CS/SF-based NFs, particularly those containing ZnO, are promising candidates for advanced wound dressing applications due to their enhanced structural integrity and biological functionality.
dc.description.sponsorshipHealth Institutes of Turkiye (TUSEB) [28428]
dc.description.sponsorshipThis work was supported by the Health Institutes of Turkiye (TUSEB) (project no: 28428).
dc.identifier.doi10.1002/app.57941
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105016325126
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org./10.1002/app.57941
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10585
dc.identifier.volume143
dc.identifier.wosWOS:001572450100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260128
dc.subjectchitosan
dc.subjectelectrospinning
dc.subjectmechanical properties
dc.subjectnanofiber
dc.subjectsilk fibroin
dc.subjectswelling
dc.subjectthermogravimetric analysis (TGA)
dc.subjecttitanium dioxide
dc.subjectwound dressing
dc.subjectzinc oxide
dc.titleDevelopment of Chitosan and Silk Fibroin Nanofibers Incorporated With ZnO and TiO2 Nanoparticles for Wound Dressing Applications
dc.typeArticle

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