Fabrication of Drug-Loaded 3D-Printed Bone Scaffolds with Radial Gradient Porosity

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dc.contributor.authorEryildiz, Meltem
dc.date.accessioned2024-03-13T10:30:51Z
dc.date.available2024-03-13T10:30:51Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractAs a result of the combination of better mechanical and biological properties, gradient porous scaffolds are becoming more and more interesting alternatives for bioengineering and medical implants. In this study, drug-loaded functionally radial gradient scaffolds were investigated. Drug-loaded polylactic acid scaffolds with radial gradient porosities with different infill zones that mimic the heterogeneous bone structure were designed and manufactured. The PLA scaffolds with radial gradients were produced using the fused deposition modeling (FDM) method with gyroid infill Homogeneous porosity scaffolds were also tested to compare the results. The porosity, cell proliferation, drug release, and compressive strength of the fabricated 3D printed scaffolds were all tested in vitro. According to findings, the scaffolds with radial gradients contained the highest cell proliferation and drug release results but exhibited decreased mechanical strength because of the increased porosity. The drug-loaded radial gradient scaffolds fabricated in this work could be used as bone scaffolds to supply antibiotics, and they have compressive strength and cell proliferation levels that are comparable to real bones. [GRAPHICS] .en_US
dc.identifier.doi10.1007/s11665-022-07490-0
dc.identifier.endpage4257en_US
dc.identifier.issn1059-9495
dc.identifier.issn1544-1024
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85140127916en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4249en_US
dc.identifier.urihttps://doi.org/10.1007/s11665-022-07490-0
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3557
dc.identifier.volume32en_US
dc.identifier.wosWOS:000870112700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Materials Engineering And Performanceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcell proliferationen_US
dc.subjectcompressive strengthen_US
dc.subjectdrug releaseen_US
dc.subjectradial gradient porosityen_US
dc.subjectscaffolden_US
dc.titleFabrication of Drug-Loaded 3D-Printed Bone Scaffolds with Radial Gradient Porosityen_US
dc.typeArticleen_US

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