Effectiveness of Different Surgical Flap Delay Methods and Their Systemic Toxicities

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dc.contributor.authorYildiz, Kemalettin
dc.contributor.authorMirapoglu, Semih Lutfi
dc.contributor.authorKilic, Ulkan
dc.contributor.authorGuneren, Ethem
dc.contributor.authorKocyigit, Abdurrahim
dc.contributor.authorKirazoglu, Ahmet
dc.contributor.authorSagir, Haci Omer
dc.date.accessioned2024-03-13T10:35:34Z
dc.date.available2024-03-13T10:35:34Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective: The surgical flap delaying has been shown to be effective in preventing partial flap loss or in preparing larger flaps. However, there is no gold standard flap delay method in the literature. In this study, the authors aimed to compare 3 types of surgical delay methods to determine which model would increase more flap survival. The authors also investigated the effect of delay methods on circulating mononuclear leukocytes as a parameter of DNA damage. Methods: Twenty-four Sprague-Dawley male rats were divided into 4 groups. All subjects had a 10 x 3 cm modified McFarlane flap. Surface area measurements, biopsies, and blood samples were taken on the day of sacrification; 7th day for the control group and 14th day for delay groups. Results: Between incisional surgery delay groups, a significant difference was found in necrosis and apoptosis in the bipedicled group, and only necrosis in the tripedicled group compared to the control. In terms of DNA damage, it was found higher in all experimental groups than in the control group. Conclusions: Both incisional surgical delay procedures' results were meaningfully effective when only incisions were made without the elevation of flaps. In conclusion, bipedicled incisional surgical delay seems to be the most effective method in McFarlane experimental flap model whereas two-staged surgeries may increase the risk of systemic toxicity.en_US
dc.identifier.doi10.1097/SCS.0000000000007444
dc.identifier.endpage1950en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue5en_US
dc.identifier.pmid33464774en_US
dc.identifier.scopus2-s2.0-85112863105en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1946en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000007444
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4492
dc.identifier.volume32en_US
dc.identifier.wosWOS:000671116400123en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectDNA damageen_US
dc.subjectflap survivalen_US
dc.subjectnecrosisen_US
dc.subjectsurgical delayen_US
dc.titleEffectiveness of Different Surgical Flap Delay Methods and Their Systemic Toxicitiesen_US
dc.typeArticleen_US

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