Maternal neuropeptide galanin levels in pregnancies with intra-uterine growth restriction (IUGR): neurohormonal regulation of fetal weight

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dc.contributor.authorKilic, Berna Sermin
dc.contributor.authorAtakul, Nil
dc.contributor.authorSelek, Sahabettin
dc.contributor.authorAtamer, Yildiz
dc.date.accessioned2024-03-13T10:30:52Z
dc.date.available2024-03-13T10:30:52Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractAim Galanin is a neuroendocrine peptide with diverse biological actions in humans. Here, we evaluated plasma galanin levels in pregnant women with intrauterine growth restriction (IUGR) to elucidate the mechanism underlying the causal link between regulatory neuropeptides and IUGR. Material and methods This prospective case-control study evaluated 40 IUGR pregnancies and 35 healthy body mass index (BMI) and age-matched second and third-trimester pregnant women at Istanbul Teaching and Research Hospital. Serums galanin levels were determined using an enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's procedure. Results Median serum galanin levels were lower in the IUGR group (9.59 pg/ml) than in the control group (12.1 pg/ml), although statically insignificant. Galanin levels were significantly higher in the control group with a BMI >= 30 than in those with a BMI < 30; the IUGR group exhibited no significant difference. Galanin levels were higher in the control group premature births than in term pregnancies; the difference was insignificant in the IUGR group. Thus, IUGR minimally impacts circulating maternal galanin levels, indicating that while galanin might affect IUGR pathogenesis, it negligibly contributes to disease progression. Conclusion The lack of correlation between galanin levels and maternal BMI and preterm pregnancies suggests a blunted neuropeptide response to hormonal stimulus in IUGR pregnancies, compared with the positive association with maternal BMI and negative association with healthy preterm pregnancies.en_US
dc.identifier.doi10.1007/s11845-022-03132-5
dc.identifier.endpage1264en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue3en_US
dc.identifier.pmid35996067en_US
dc.identifier.scopus2-s2.0-85136713846en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1259en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-022-03132-5
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3568
dc.identifier.volume192en_US
dc.identifier.wosWOS:000842866500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFetal growthen_US
dc.subjectGalaninen_US
dc.subjectGestational weight (GW)en_US
dc.subjectIntrauterine growth restriction (IUGR)en_US
dc.titleMaternal neuropeptide galanin levels in pregnancies with intra-uterine growth restriction (IUGR): neurohormonal regulation of fetal weighten_US
dc.typeArticleen_US

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