Novel metabolic marker Afamin: A predictive factor for Large-for-Gestational-Age (LGA) fetus estimation in pregnancies with gestational diabetes mellitus?

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dc.contributor.authorAtakul, Nil
dc.contributor.authorAtamer, Yildiz
dc.contributor.authorSelek, Sahabettin
dc.contributor.authorKilic, Berna Sermin
dc.contributor.authorUnal, Fehmi
dc.date.accessioned2024-03-13T10:34:59Z
dc.date.available2024-03-13T10:34:59Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective: Gestational diabetes mellitus (GDM) affects both maternal and fetal/infant outcomes during and after pregnancy. The reason for the high incidence of large-for-gestational-age (LGA) infants in GDM patients despite close monitorization of glucose levels with early detection of the disease remains unclear to date. Our study aims to investigate the levels of the third-trimester novel marker afamin in GDM versus non-GDM pregnancies in terms of glycemic control status and their utility in the prediction of LGA fetuses. Material and Methods: This prospective case-control study analysis involved 49 pregnant women with GDM diagnosed using the 75-g oral glucose tolerance test (75-g OGTT) and 40 randomly selected women with a similar body mass index (BMI) and gestational age (GA). Blood samples were collected in the third trimester of pregnancy. The afamin level was determined using a human afamin ELISA kit according to the manufacturer's procedure. Results: There was no significant difference found in BMI or GA of patients. Third-trimester afamin levels were 93.91 mg/L and 83.87 mg/L in the GDM and non-GDM groups, respectively (p=0.625). Afamin values of patients were not correlated with age, BMI, GA, HgA1c, 75-g OGTT fasting and 75-g OGTT 1-hour, or 75-g OGTT 2-hour values (p>0.05). GDM patients with LGA fetuses had significantly higher afamin values than patients with appropriate-for-gestational-age (AGA) fetuses (120.8 mg/L versus 91.26 mg/L, respectively). Between GDM patients with either LGA or AGA fetuses, there was no statistically significant difference found for age, BMI, GAs, insulin dose, 75-g OGTT results, or HgA1c values. Conclusion: Our findings conclude that novel marker afamin levels could predict the risk of LGA infants independently of glycemic control status and provide insight into the pathogenesis of LGA fetuses, thus helping to reduce the risk of associated complications. (C) 2021 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.jogoh.2021.102201
dc.identifier.issn2468-7847
dc.identifier.issn1773-0430
dc.identifier.issue10en_US
dc.identifier.pmid34365029en_US
dc.identifier.scopus2-s2.0-85112759981en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jogoh.2021.102201
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4200
dc.identifier.volume50en_US
dc.identifier.wosWOS:000703908600013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson, Corp Offen_US
dc.relation.ispartofJournal Of Gynecology Obstetrics And Human Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAfaminen_US
dc.subjectGestational diabetes mellitus (GDM)en_US
dc.subjectLarge for gestational age (LGA)en_US
dc.subject75gr-Oral Glucose Tolerance Test (OGTT)en_US
dc.titleNovel metabolic marker Afamin: A predictive factor for Large-for-Gestational-Age (LGA) fetus estimation in pregnancies with gestational diabetes mellitus?en_US
dc.typeArticleen_US

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