Toxic epidermal necrolysis after cranial radiotherapy and phenytoin treatment

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dc.contributor.authorDincbas, FO
dc.contributor.authorYörük, S
dc.contributor.authorDemirkesen, C
dc.contributor.authorUzel, O
dc.contributor.authorKoca, S
dc.date.accessioned2024-03-13T10:32:58Z
dc.date.available2024-03-13T10:32:58Z
dc.date.issued2004
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: There are few reports about Stevens-Johnson syndrome, a bullous form of erythema multiforme, that can develop in patients treated with cranial irradiation and antiepileptic drugs, especially with phenytoin. We present a patient who developed toxic epidermal necrolysis, a rare and severe form of Stevens-Johnson syndrome, during cranial radiotherapy and phenytoin treatment. Case Report: A 65-year-old male patient with stage IIIB non-small cell lung carcinoma developed a brain metastasis. The patient was treated with phenytoin and dexamethasone. Palliative total cranial irradiation was performed. On the 23rd day of phenytoin administration, erythema and edema in the radiotherapy area and lips, as well as widespread maculopapular eruptions and rashes in the upper thoracic area were observed. The dermal lesions progressed to bullae and subsequently toxic epidermal necrolysis covering 70% of the whole body surface developed. The patient died within 15 days of appearance of the lesions due to secondary infections, despite supportive and symptomatic treatment. Conclusion: Although toxic epidermal necrolysis is a rare toxicity it must always be considered during cranial irradiation and antiepileptic prophylaxis.en_US
dc.identifier.doi10.1159/000079094
dc.identifier.endpage392en_US
dc.identifier.issn0378-584X
dc.identifier.issue4en_US
dc.identifier.pmid15347896en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://doi.org/10.1159/000079094
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3705
dc.identifier.volume27en_US
dc.identifier.wosWOS:000223980600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOnkologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectphenytoinen_US
dc.subjecttoxic epidermal necrolysisen_US
dc.subjectbrain irradiationen_US
dc.titleToxic epidermal necrolysis after cranial radiotherapy and phenytoin treatmenten_US
dc.typeArticleen_US

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