Helicobacter pylori-miRNA interaction in gastric cancer tissues: First prospective study from Turkey

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dc.contributor.authorDemiryas, Suleyman
dc.contributor.authorKocazeybek, Bekir
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorCaliskan, Reyhan
dc.contributor.authorKepil, Nuray
dc.contributor.authorUysal, Hayriye Kirkoyun
dc.contributor.authorDinc, Harika Oyku
dc.date.accessioned2024-03-13T10:33:39Z
dc.date.available2024-03-13T10:33:39Z
dc.date.issued2019
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractHelicobacter pylori (H. pylori) is involved in the etiology of gastric cancer (GC). miRNAs are short RNAs that regulate gene expression by marking mRNAs for degradation. miRNAs are involved in tumorigenesis, metastasis, and cell proliferation. We aimed to investigate the miRNA expression profiles of tissues from H. pylori Wand (-) GC patients. Forty GC patients, 20 H. pylori Wand 20 H. pylori (-), and a healthy control group were included. The miRNA expression levels were investigated by microarrays and quantitative RT-PCR. We detected 9 upregulated and 4 downregulated miRNAs by microarray. We selected 5 upregulated and 5 downregulated miRNAs for the quantitative RT-PCR assay. The relative fold changes of miRNAs in the cancerous tissue and non-tumor mucosa specimens of H. pylori (+) GC patients for hsa-miR-194 were 4.24- and 3.83-fold higher, respectively, whereas the hsa-miR-145 expression levels were downregulated 0.33-fold and 0.43-fold, respectively, in the same group. The presence of H. pylori significantly upregulated hsa-miR-194 and downregulated hsa-miR-145 expression levels in H. pylofi(+)GC cases, compared to H. pylori (-) GC cases. Regional differences in the virulence of H. pylori strains may also be involved in the up- or downregulation of miRNA expression levels.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects Coordination Unit [TYO-22255]en_US
dc.description.sponsorshipThis work was supported by the Istanbul University Scientific Research Projects Coordination Unit. Project number:TYO-22255.en_US
dc.identifier.endpage220en_US
dc.identifier.issn1121-7138
dc.identifier.issue4en_US
dc.identifier.pmid31524946en_US
dc.identifier.scopus2-s2.0-85075814779en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4077
dc.identifier.volume42en_US
dc.identifier.wosWOS:000499241500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Int Srlen_US
dc.relation.ispartofNew Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectmiRNAen_US
dc.subjectgastric canceren_US
dc.titleHelicobacter pylori-miRNA interaction in gastric cancer tissues: First prospective study from Turkeyen_US
dc.typeArticleen_US

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